An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism
The use of synthetic organisms could provide opportunities for discovery and advanced manufacturing of medical drugs. Here the authors use a semi-synthetic organism with an expanded genetic code to generate site-specific chemical modifications in human IL-2.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24987-9 |
| _version_ | 1818751807772426240 |
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| author | Jerod L. Ptacin Carolina E. Caffaro Lina Ma Kristine M. San Jose Gall Hans R. Aerni Nicole V. Acuff Rob W. Herman Yelena Pavlova Michael J. Pena David B. Chen Lilia K. Koriazova Laura K. Shawver Ingrid B. Joseph Marcos E. Milla |
| author_facet | Jerod L. Ptacin Carolina E. Caffaro Lina Ma Kristine M. San Jose Gall Hans R. Aerni Nicole V. Acuff Rob W. Herman Yelena Pavlova Michael J. Pena David B. Chen Lilia K. Koriazova Laura K. Shawver Ingrid B. Joseph Marcos E. Milla |
| author_sort | Jerod L. Ptacin |
| collection | DOAJ |
| description | The use of synthetic organisms could provide opportunities for discovery and advanced manufacturing of medical drugs. Here the authors use a semi-synthetic organism with an expanded genetic code to generate site-specific chemical modifications in human IL-2. |
| first_indexed | 2024-12-18T04:41:26Z |
| format | Article |
| id | doaj.art-1eeb5f339edc4637a3c9f0f0c17dcf95 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:41:26Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1eeb5f339edc4637a3c9f0f0c17dcf952022-12-21T21:20:42ZengNature PortfolioNature Communications2041-17232021-08-0112111410.1038/s41467-021-24987-9An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organismJerod L. Ptacin0Carolina E. Caffaro1Lina Ma2Kristine M. San Jose Gall3Hans R. Aerni4Nicole V. Acuff5Rob W. Herman6Yelena Pavlova7Michael J. Pena8David B. Chen9Lilia K. Koriazova10Laura K. Shawver11Ingrid B. Joseph12Marcos E. Milla13Synthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanySynthorx, Inc., a Sanofi CompanyThe use of synthetic organisms could provide opportunities for discovery and advanced manufacturing of medical drugs. Here the authors use a semi-synthetic organism with an expanded genetic code to generate site-specific chemical modifications in human IL-2.https://doi.org/10.1038/s41467-021-24987-9 |
| spellingShingle | Jerod L. Ptacin Carolina E. Caffaro Lina Ma Kristine M. San Jose Gall Hans R. Aerni Nicole V. Acuff Rob W. Herman Yelena Pavlova Michael J. Pena David B. Chen Lilia K. Koriazova Laura K. Shawver Ingrid B. Joseph Marcos E. Milla An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism Nature Communications |
| title | An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism |
| title_full | An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism |
| title_fullStr | An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism |
| title_full_unstemmed | An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism |
| title_short | An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism |
| title_sort | engineered il 2 reprogrammed for anti tumor therapy using a semi synthetic organism |
| url | https://doi.org/10.1038/s41467-021-24987-9 |
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