Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis
Entamoeba histolytica, the protozoan parasite causing human amoebisis, has recently been found to comprise two genetically distinct forms, potentially pathogenic and constitutively nonpathogenic ones. Host tissue destruction by pathogenic forms is belived to result from cell functions mediaed by a l...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1992-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900007 |
| _version_ | 1797718338664660992 |
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| author | Rolf D. Horstmann Mathias Leippe Egbert Tannich |
| author_facet | Rolf D. Horstmann Mathias Leippe Egbert Tannich |
| author_sort | Rolf D. Horstmann |
| collection | DOAJ |
| description | Entamoeba histolytica, the protozoan parasite causing human amoebisis, has recently been found to comprise two genetically distinct forms, potentially pathogenic and constitutively nonpathogenic ones. Host tissue destruction by pathogenic forms is belived to result from cell functions mediaed by a lectin-type adherence receptor, a pore-forming peptide involved in host cell lysis, and abundant expression of cysteine proteinase(s). Isolation and molecular cloning of these amoeba products have provided the tools for structural analyses and manipulations of cell functions including comparisons between pathogenic and nonpathogenic forms. |
| first_indexed | 2024-03-12T08:49:35Z |
| format | Article |
| id | doaj.art-1eee92d0e988489bade8bdb84c694a1e |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:49:35Z |
| publishDate | 1992-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-1eee92d0e988489bade8bdb84c694a1e2023-09-02T16:21:59ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601992-01-0187576010.1590/S0074-02761992000900007Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysisRolf D. HorstmannMathias LeippeEgbert TannichEntamoeba histolytica, the protozoan parasite causing human amoebisis, has recently been found to comprise two genetically distinct forms, potentially pathogenic and constitutively nonpathogenic ones. Host tissue destruction by pathogenic forms is belived to result from cell functions mediaed by a lectin-type adherence receptor, a pore-forming peptide involved in host cell lysis, and abundant expression of cysteine proteinase(s). Isolation and molecular cloning of these amoeba products have provided the tools for structural analyses and manipulations of cell functions including comparisons between pathogenic and nonpathogenic forms.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900007taxonomyparasite pathogenicityamoebiasis |
| spellingShingle | Rolf D. Horstmann Mathias Leippe Egbert Tannich Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis Memorias do Instituto Oswaldo Cruz taxonomy parasite pathogenicity amoebiasis |
| title | Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis |
| title_full | Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis |
| title_fullStr | Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis |
| title_full_unstemmed | Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis |
| title_short | Host tissue destruction by Entamoeba histolytica: molecules mediating adhesion, cytolysis, and proteolysis |
| title_sort | host tissue destruction by entamoeba histolytica molecules mediating adhesion cytolysis and proteolysis |
| topic | taxonomy parasite pathogenicity amoebiasis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000900007 |
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