Transplacental passage of hyperforin, hypericin, and valerenic acid
Safe medications for mild mental diseases in pregnancy are needed. Phytomedicines from St. John’s wort and valerian are valid candidates, but safety data in pregnancy are lacking. The transplacental transport of hyperforin and hypericin (from St. John’s wort), and valerenic acid (from valerian) was...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1123194/full |
| _version_ | 1827975511547052032 |
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| author | Deborah Spiess Deborah Spiess Vanessa Fabienne Abegg Antoine Chauveau Joshua Rath Andrea Treyer Michael Reinehr Sabrina Kuoni Mouhssin Oufir Olivier Potterat Matthias Hamburger Ana Paula Simões-Wüst |
| author_facet | Deborah Spiess Deborah Spiess Vanessa Fabienne Abegg Antoine Chauveau Joshua Rath Andrea Treyer Michael Reinehr Sabrina Kuoni Mouhssin Oufir Olivier Potterat Matthias Hamburger Ana Paula Simões-Wüst |
| author_sort | Deborah Spiess |
| collection | DOAJ |
| description | Safe medications for mild mental diseases in pregnancy are needed. Phytomedicines from St. John’s wort and valerian are valid candidates, but safety data in pregnancy are lacking. The transplacental transport of hyperforin and hypericin (from St. John’s wort), and valerenic acid (from valerian) was evaluated using the ex vivo cotyledon perfusion model (4 h perfusions, term placentae) and, in part, the in vitro Transwell assay with BeWo b30 cells. Antipyrine was used for comparison in both models. U(H)PLC-MS/MS bioanalytical methods were developed to quantify the compounds. Perfusion data obtained with term placentae showed that only minor amounts of hyperforin passed into the fetal circuit, while hypericin did not cross the placental barrier and valerenic acid equilibrated between the maternal and fetal compartments. None of the investigated compounds affected metabolic, functional, and histopathological parameters of the placenta during the perfusion experiments. Data from the Transwell model suggested that valerenic acid does not cross the placental cell layer. Taken together, our data suggest that throughout the pregnancy the potential fetal exposure to hypericin and hyperforin – but not to valerenic acid – is likely to be minimal. |
| first_indexed | 2024-04-09T20:12:51Z |
| format | Article |
| id | doaj.art-1eefad6644e44b5a8fd8513a0ff5693e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T20:12:51Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-1eefad6644e44b5a8fd8513a0ff5693e2023-03-31T16:18:12ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-03-011410.3389/fphar.2023.11231941123194Transplacental passage of hyperforin, hypericin, and valerenic acidDeborah Spiess0Deborah Spiess1Vanessa Fabienne Abegg2Antoine Chauveau3Joshua Rath4Andrea Treyer5Michael Reinehr6Sabrina Kuoni7Mouhssin Oufir8Olivier Potterat9Matthias Hamburger10Ana Paula Simões-Wüst11Department of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandDivision of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, SwitzerlandDivision of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, SwitzerlandDivision of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, SwitzerlandDepartment of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandDivision of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, SwitzerlandDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, SwitzerlandDepartment of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandDivision of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, SwitzerlandDivision of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, SwitzerlandDivision of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, SwitzerlandDepartment of Obstetrics, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandSafe medications for mild mental diseases in pregnancy are needed. Phytomedicines from St. John’s wort and valerian are valid candidates, but safety data in pregnancy are lacking. The transplacental transport of hyperforin and hypericin (from St. John’s wort), and valerenic acid (from valerian) was evaluated using the ex vivo cotyledon perfusion model (4 h perfusions, term placentae) and, in part, the in vitro Transwell assay with BeWo b30 cells. Antipyrine was used for comparison in both models. U(H)PLC-MS/MS bioanalytical methods were developed to quantify the compounds. Perfusion data obtained with term placentae showed that only minor amounts of hyperforin passed into the fetal circuit, while hypericin did not cross the placental barrier and valerenic acid equilibrated between the maternal and fetal compartments. None of the investigated compounds affected metabolic, functional, and histopathological parameters of the placenta during the perfusion experiments. Data from the Transwell model suggested that valerenic acid does not cross the placental cell layer. Taken together, our data suggest that throughout the pregnancy the potential fetal exposure to hypericin and hyperforin – but not to valerenic acid – is likely to be minimal.https://www.frontiersin.org/articles/10.3389/fphar.2023.1123194/fullhyperforinhypericinvalerenic acidHypericum perforatumValeriana officinalisplacental perfusion |
| spellingShingle | Deborah Spiess Deborah Spiess Vanessa Fabienne Abegg Antoine Chauveau Joshua Rath Andrea Treyer Michael Reinehr Sabrina Kuoni Mouhssin Oufir Olivier Potterat Matthias Hamburger Ana Paula Simões-Wüst Transplacental passage of hyperforin, hypericin, and valerenic acid Frontiers in Pharmacology hyperforin hypericin valerenic acid Hypericum perforatum Valeriana officinalis placental perfusion |
| title | Transplacental passage of hyperforin, hypericin, and valerenic acid |
| title_full | Transplacental passage of hyperforin, hypericin, and valerenic acid |
| title_fullStr | Transplacental passage of hyperforin, hypericin, and valerenic acid |
| title_full_unstemmed | Transplacental passage of hyperforin, hypericin, and valerenic acid |
| title_short | Transplacental passage of hyperforin, hypericin, and valerenic acid |
| title_sort | transplacental passage of hyperforin hypericin and valerenic acid |
| topic | hyperforin hypericin valerenic acid Hypericum perforatum Valeriana officinalis placental perfusion |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1123194/full |
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