Direct Measurement of the Affinity between tBid and Bax in a Mitochondria-Like Membrane

Direct Measurement of the Affinity between tBid and Bax in a Mitochondria-Like Membrane

The execution step in apoptosis is the permeabilization of the outer mitochondrial membrane, controlled by Bcl-2 family proteins. The physical interactions between the different proteins in this family and their relative abundance literally determine the fate of the cells. These interactions, howeve...

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Bibliographic Details
Main Authors: Markus Rose, Martin Kurylowicz, Mohammad Mahmood, Sheldon Winkel, Jose M. Moran-Mirabal, Cécile Fradin
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
mitochondria
Bcl-2 family
Bax
Bid
membrane protein
Online Access:https://www.mdpi.com/1422-0067/22/15/8240

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