5-Aminolevulinic Acid False-Positive Rates in Newly Diagnosed and Recurrent Glioblastoma: Do Pseudoprogression and Radionecrosis Play a Role? A Meta-Analysis

5-Aminolevulinic Acid False-Positive Rates in Newly Diagnosed and Recurrent Glioblastoma: Do Pseudoprogression and Radionecrosis Play a Role? A Meta-Analysis

BackgroundSeveral studies have confirmed the impact of 5-aminolevulinic acid (5-ALA) on the extent of resection in newly diagnosed glioblastoma (GBM). However, there are controversies on the 5-ALA fluorescence status in recurrent GBM surgery, with specific reference to pseudoprogression or radionecr...

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Bibliographic Details
Main Authors: Luca Ricciardi, Carmelo Lucio Sturiale, Alba Scerrati, Vito Stifano, Teresa Somma, Tamara Ius, Sokol Trungu, Michele Acqui, Antonino Raco, Massimo Miscusi, Giuseppe Maria Della Pepa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
high-grade glioma (HGG)
recurrent glioblastoma
5-ALA fluorescence
pseudoprogression
radionecrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.848036/full

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