EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY
Peripheral blood monocytes play a key role in regulation of immune response during pregnancy. Intensive adhesion of monocytes to endothelium proves that monocytes are activated during pregnancy. To determine a potential role of adhesion molecules for ability of monocytes to adhere, we studied expres...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/150 |
| _version_ | 1826534370536587264 |
|---|---|
| author | V. A. Mikhaylova Y. S. Klimovskaya N. V. Amanova M. S. Zaynulina S. A. Selkov D. I. Sokolov |
| author_facet | V. A. Mikhaylova Y. S. Klimovskaya N. V. Amanova M. S. Zaynulina S. A. Selkov D. I. Sokolov |
| author_sort | V. A. Mikhaylova |
| collection | DOAJ |
| description | Peripheral blood monocytes play a key role in regulation of immune response during pregnancy. Intensive adhesion of monocytes to endothelium proves that monocytes are activated during pregnancy. To determine a potential role of adhesion molecules for ability of monocytes to adhere, we studied expression of CD11a, CD11b, CD11c, CD18, CD49d, CD29 markers of monocytes from non-pregnant and pregnant women. Expression of adhesion molecules on monocytes was analyzed by flow cytometry. The amounts of CD11b-expressing monocytes increased during pregnancy, as compared with non-pregnant women. Intensity of CD11a, CD11b, CD11c, CD29 expression on the monocytes did also increase at normal pregnancy. These results suggest that intense adhesion of monocytes to endothelium during uncomplicated pregnancy may be determined by increased expression of CD11a, CD11b, CD11c, CD29, and higher amounts of CD11b+ monocytes. |
| first_indexed | 2024-03-08T05:51:22Z |
| format | Article |
| id | doaj.art-1ef47a6792b541e28cace2539b7e2ec2 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:21:57Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-1ef47a6792b541e28cace2539b7e2ec22025-03-11T17:59:00ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01124-533734210.15789/1563-0625-2010-4-5-337-342147EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCYV. A. Mikhaylova0Y. S. Klimovskaya1N. V. Amanova2M. S. Zaynulina3S. A. Selkov4D. I. Sokolov5Учреждение Российской академии медицинских наук Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта Северо-Западного отделения РАМН, Санкт-ПетербургУчреждение Российской академии медицинских наук Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта Северо-Западного отделения РАМН, Санкт-ПетербургУчреждение Российской академии медицинских наук Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта Северо-Западного отделения РАМН, Санкт-ПетербургУчреждение Российской академии медицинских наук Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта Северо-Западного отделения РАМН, Санкт-ПетербургУчреждение Российской академии медицинских наук Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта Северо-Западного отделения РАМН, Санкт-ПетербургУчреждение Российской академии медицинских наук Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта Северо-Западного отделения РАМН, Санкт-ПетербургPeripheral blood monocytes play a key role in regulation of immune response during pregnancy. Intensive adhesion of monocytes to endothelium proves that monocytes are activated during pregnancy. To determine a potential role of adhesion molecules for ability of monocytes to adhere, we studied expression of CD11a, CD11b, CD11c, CD18, CD49d, CD29 markers of monocytes from non-pregnant and pregnant women. Expression of adhesion molecules on monocytes was analyzed by flow cytometry. The amounts of CD11b-expressing monocytes increased during pregnancy, as compared with non-pregnant women. Intensity of CD11a, CD11b, CD11c, CD29 expression on the monocytes did also increase at normal pregnancy. These results suggest that intense adhesion of monocytes to endothelium during uncomplicated pregnancy may be determined by increased expression of CD11a, CD11b, CD11c, CD29, and higher amounts of CD11b+ monocytes.https://www.mimmun.ru/mimmun/article/view/150monocytesadhesion moleculespregnancy |
| spellingShingle | V. A. Mikhaylova Y. S. Klimovskaya N. V. Amanova M. S. Zaynulina S. A. Selkov D. I. Sokolov EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY Медицинская иммунология monocytes adhesion molecules pregnancy |
| title | EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY |
| title_full | EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY |
| title_fullStr | EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY |
| title_full_unstemmed | EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY |
| title_short | EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY |
| title_sort | expression of adhesion molecules on peripheral blood monocytes during pregnancy |
| topic | monocytes adhesion molecules pregnancy |
| url | https://www.mimmun.ru/mimmun/article/view/150 |
| work_keys_str_mv | AT vamikhaylova expressionofadhesionmoleculesonperipheralbloodmonocytesduringpregnancy AT ysklimovskaya expressionofadhesionmoleculesonperipheralbloodmonocytesduringpregnancy AT nvamanova expressionofadhesionmoleculesonperipheralbloodmonocytesduringpregnancy AT mszaynulina expressionofadhesionmoleculesonperipheralbloodmonocytesduringpregnancy AT saselkov expressionofadhesionmoleculesonperipheralbloodmonocytesduringpregnancy AT disokolov expressionofadhesionmoleculesonperipheralbloodmonocytesduringpregnancy |