Protective Effect of Melatonin on Aluminum Accumulation in Some Organs of Rats
This study emphasizes the protective effect of melatonin against the aluminum accumulation in some organs of rats. Twenty eight male Wistar rats were divided into four groups (n=7 animals for each), one control and three experimental, and aluminum sulphate and melatonin were applied in drinking wate...
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| Format: | Article |
| Language: | English |
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Istanbul University
2015-01-01
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| Series: | İstanbul Üniversitesi Veteriner Fakültesi Dergisi |
| Subjects: | |
| Online Access: | http://www.journals.istanbul.edu.tr/iuvfd/article/view/5000079114/5000076526 |
| _version_ | 1797909877436186624 |
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| author | Florin MUSELIN Eugenia DUMITRESCU Romeo CRISTINA Alexandru DOMA Alexandra TRIF |
| author_facet | Florin MUSELIN Eugenia DUMITRESCU Romeo CRISTINA Alexandru DOMA Alexandra TRIF |
| author_sort | Florin MUSELIN |
| collection | DOAJ |
| description | This study emphasizes the protective effect of melatonin against the aluminum accumulation in some organs of rats. Twenty eight male Wistar rats were divided into four groups (n=7 animals for each), one control and three experimental, and aluminum sulphate and melatonin were applied in drinking water for three months as follows: group I: aluminum sulphate (1000 ppb in water), group II: aluminum sulphate (1000 ppb in water) and melatonin (10 mg in 100 mL water) and group III: melatonin (10 mg in100 mL water). Control group: water. Aluminum was accumulated in liver, kidney, heart, spleen and brain of exposed rats in significantly higher amounts compared to the control group. The findings showed that melatonin administration reduced the aluminum level in studied organs and melatonin had a protective effect against aluminum accumulation. |
| first_indexed | 2024-04-10T11:15:21Z |
| format | Article |
| id | doaj.art-1ef4c09fdec24f1face30600f4fc2e1c |
| institution | Directory Open Access Journal |
| issn | 0250-2836 0250-2836 |
| language | English |
| last_indexed | 2024-04-10T11:15:21Z |
| publishDate | 2015-01-01 |
| publisher | Istanbul University |
| record_format | Article |
| series | İstanbul Üniversitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-1ef4c09fdec24f1face30600f4fc2e1c2023-02-15T16:18:52ZengIstanbul Universityİstanbul Üniversitesi Veteriner Fakültesi Dergisi0250-28360250-28362015-01-01411263010.16988/iuvfd.2015.88209Protective Effect of Melatonin on Aluminum Accumulation in Some Organs of RatsFlorin MUSELIN0Eugenia DUMITRESCU1Romeo CRISTINA2Alexandru DOMA3Alexandra TRIF4Faculty of Veterinary Medicine, Department of Toxicology, Banat’s University of Agricultural Sciences and Veterinary Medicine Timişoara, Calea Aradului Nr. 119, 300 645 Timişoara, RomaniaFaculty of Veterinary Medicine, Department of Pharmacology, Banat’s University of Agricultural Sciences and Veterinary Medicine Timişoara, Calea Aradului Nr. 119, 300 645 Timişoara, RomaniaFaculty of Veterinary Medicine, Department of Pharmacology, Banat’s University of Agricultural Sciences and Veterinary Medicine Timişoara, Calea Aradului Nr. 119, 300 645 Timişoara, RomaniaFaculty of Veterinary Medicine, Department of Pharmacology, Banat’s University of Agricultural Sciences and Veterinary Medicine Timişoara, Calea Aradului Nr. 119, 300 645 Timişoara, RomaniaFaculty of Veterinary Medicine, Department of Toxicology, Banat’s University of Agricultural Sciences and Veterinary Medicine Timişoara, Calea Aradului Nr. 119, 300 645 Timişoara, RomaniaThis study emphasizes the protective effect of melatonin against the aluminum accumulation in some organs of rats. Twenty eight male Wistar rats were divided into four groups (n=7 animals for each), one control and three experimental, and aluminum sulphate and melatonin were applied in drinking water for three months as follows: group I: aluminum sulphate (1000 ppb in water), group II: aluminum sulphate (1000 ppb in water) and melatonin (10 mg in 100 mL water) and group III: melatonin (10 mg in100 mL water). Control group: water. Aluminum was accumulated in liver, kidney, heart, spleen and brain of exposed rats in significantly higher amounts compared to the control group. The findings showed that melatonin administration reduced the aluminum level in studied organs and melatonin had a protective effect against aluminum accumulation.http://www.journals.istanbul.edu.tr/iuvfd/article/view/5000079114/5000076526Aluminumorgan accumulationmelatoninrats |
| spellingShingle | Florin MUSELIN Eugenia DUMITRESCU Romeo CRISTINA Alexandru DOMA Alexandra TRIF Protective Effect of Melatonin on Aluminum Accumulation in Some Organs of Rats İstanbul Üniversitesi Veteriner Fakültesi Dergisi Aluminum organ accumulation melatonin rats |
| title | Protective Effect of Melatonin on Aluminum Accumulation in Some Organs of Rats |
| title_full | Protective Effect of Melatonin on Aluminum Accumulation in Some Organs of Rats |
| title_fullStr | Protective Effect of Melatonin on Aluminum Accumulation in Some Organs of Rats |
| title_full_unstemmed | Protective Effect of Melatonin on Aluminum Accumulation in Some Organs of Rats |
| title_short | Protective Effect of Melatonin on Aluminum Accumulation in Some Organs of Rats |
| title_sort | protective effect of melatonin on aluminum accumulation in some organs of rats |
| topic | Aluminum organ accumulation melatonin rats |
| url | http://www.journals.istanbul.edu.tr/iuvfd/article/view/5000079114/5000076526 |
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