Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease

Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease

Abstract It was recently revealed that gut microbiota promote amyloid-beta (Aβ) burden in mouse models of Alzheimer’s disease (AD). However, the underlying mechanisms when using either germ-free (GF) housing conditions or treatments with antibiotics (ABX) remained unknown. In this study, we show tha...

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Main Authors: Charlotte Mezö, Nikolaos Dokalis, Omar Mossad, Ori Staszewski, Jana Neuber, Bahtiyar Yilmaz, Daniel Schnepf, Mercedes Gomez de Agüero, Stephanie C. Ganal-Vonarburg, Andrew J. Macpherson, Melanie Meyer-Luehmann, Peter Staeheli, Thomas Blank, Marco Prinz, Daniel Erny
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Acta Neuropathologica Communications
Subjects:
Gut microbiota
Antibiotics
Germ-free
Microglia
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s40478-020-00988-5

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