Role of p53, Cancer Stem Cells, and Cellular Senescence in Radiation Response
Currently, radiotherapy has been identified as the most common cancer treatment. However, the efficacy of this treatment modality is low in several malignancies due to the resistance of cancer to radiation. Multiple mechanisms, including cell-cycle checkpoint function, DNA repair, and cell death pat...
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2023-09-01
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| Series: | International Journal of Biomedicine |
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| Online Access: | http://www.ijbm.org/articles/i51/ijbm_13(3)_ra3.pdf |
| _version_ | 1797690837749989376 |
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| author | Juan C. Alamilla-Presuel |
| author_facet | Juan C. Alamilla-Presuel |
| author_sort | Juan C. Alamilla-Presuel |
| collection | DOAJ |
| description | Currently, radiotherapy has been identified as the most common cancer treatment. However, the efficacy of this treatment modality is low in several malignancies due to the resistance of cancer to radiation. Multiple mechanisms, including cell-cycle checkpoint function, DNA repair, and cell death pathways, modulate the radio-responsiveness of cancer cells. This review considered the role of p53, cancer stem cells (CSCs), and cellular senescence in radiation response. |
| first_indexed | 2024-03-12T02:04:53Z |
| format | Article |
| id | doaj.art-1ef6d331ffa24714a76dfa8950adf14e |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-03-12T02:04:53Z |
| publishDate | 2023-09-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-1ef6d331ffa24714a76dfa8950adf14e2023-09-07T05:08:30ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292023-09-01133314510.21103/Article13(3)_RA3Role of p53, Cancer Stem Cells, and Cellular Senescence in Radiation ResponseJuan C. Alamilla-Presuel0The University of Málaga, Málaga, SpainCurrently, radiotherapy has been identified as the most common cancer treatment. However, the efficacy of this treatment modality is low in several malignancies due to the resistance of cancer to radiation. Multiple mechanisms, including cell-cycle checkpoint function, DNA repair, and cell death pathways, modulate the radio-responsiveness of cancer cells. This review considered the role of p53, cancer stem cells (CSCs), and cellular senescence in radiation response.http://www.ijbm.org/articles/i51/ijbm_13(3)_ra3.pdfp53cancer stem cellscellular senescenceradioresistance |
| spellingShingle | Juan C. Alamilla-Presuel Role of p53, Cancer Stem Cells, and Cellular Senescence in Radiation Response International Journal of Biomedicine p53 cancer stem cells cellular senescence radioresistance |
| title | Role of p53, Cancer Stem Cells, and Cellular Senescence in Radiation Response |
| title_full | Role of p53, Cancer Stem Cells, and Cellular Senescence in Radiation Response |
| title_fullStr | Role of p53, Cancer Stem Cells, and Cellular Senescence in Radiation Response |
| title_full_unstemmed | Role of p53, Cancer Stem Cells, and Cellular Senescence in Radiation Response |
| title_short | Role of p53, Cancer Stem Cells, and Cellular Senescence in Radiation Response |
| title_sort | role of p53 cancer stem cells and cellular senescence in radiation response |
| topic | p53 cancer stem cells cellular senescence radioresistance |
| url | http://www.ijbm.org/articles/i51/ijbm_13(3)_ra3.pdf |
| work_keys_str_mv | AT juancalamillapresuel roleofp53cancerstemcellsandcellularsenescenceinradiationresponse |