Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases
Abstract Background The majority of individuals with fragile X syndrome (FXS) have intellectual disability, behavioral problems, autism, and language deficits. IQ typically declines with age in boys with the full mutation. The results of preclinical studies demonstrated that metformin, a biguanide u...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-07-01
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| Series: | Molecular Genetics & Genomic Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mgg3.745 |
| _version_ | 1828530181304745984 |
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| author | Dragana Protic Elber Y. Aydin Flora Tassone Maria M. Tan Randi J. Hagerman Andrea Schneider |
| author_facet | Dragana Protic Elber Y. Aydin Flora Tassone Maria M. Tan Randi J. Hagerman Andrea Schneider |
| author_sort | Dragana Protic |
| collection | DOAJ |
| description | Abstract Background The majority of individuals with fragile X syndrome (FXS) have intellectual disability, behavioral problems, autism, and language deficits. IQ typically declines with age in boys with the full mutation. The results of preclinical studies demonstrated that metformin, a biguanide used to treat type 2 diabetes, rescues multiple phenotypes of FXS in both Drosophila and mouse models. Preliminary studies of patients with FXS demonstrated improvements in behavior. Methods Here, we present two cases of individuals who have been treated with metformin clinically for one year. Results Both patients demonstrated significant cognitive and behavioral improvements. They also improved eating habits and normalization of their weight percentiles. Conclusion Metformin may be a candidate drug for treatment of several types of symptoms in individuals with FXS. |
| first_indexed | 2024-12-11T22:19:31Z |
| format | Article |
| id | doaj.art-1ef6e582f9a0486baf251ec14b901cff |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-12-11T22:19:31Z |
| publishDate | 2019-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-1ef6e582f9a0486baf251ec14b901cff2022-12-22T00:48:29ZengWileyMolecular Genetics & Genomic Medicine2324-92692019-07-0177n/an/a10.1002/mgg3.745Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two casesDragana Protic0Elber Y. Aydin1Flora Tassone2Maria M. Tan3Randi J. Hagerman4Andrea Schneider5Medical Investigation of Neurodevelopmental Disorders (MIND) Institute University of California Davis Sacramento CaliforniaMedical Investigation of Neurodevelopmental Disorders (MIND) Institute University of California Davis Sacramento CaliforniaMedical Investigation of Neurodevelopmental Disorders (MIND) Institute University of California Davis Sacramento CaliforniaMedical Investigation of Neurodevelopmental Disorders (MIND) Institute University of California Davis Sacramento CaliforniaMedical Investigation of Neurodevelopmental Disorders (MIND) Institute University of California Davis Sacramento CaliforniaMedical Investigation of Neurodevelopmental Disorders (MIND) Institute University of California Davis Sacramento CaliforniaAbstract Background The majority of individuals with fragile X syndrome (FXS) have intellectual disability, behavioral problems, autism, and language deficits. IQ typically declines with age in boys with the full mutation. The results of preclinical studies demonstrated that metformin, a biguanide used to treat type 2 diabetes, rescues multiple phenotypes of FXS in both Drosophila and mouse models. Preliminary studies of patients with FXS demonstrated improvements in behavior. Methods Here, we present two cases of individuals who have been treated with metformin clinically for one year. Results Both patients demonstrated significant cognitive and behavioral improvements. They also improved eating habits and normalization of their weight percentiles. Conclusion Metformin may be a candidate drug for treatment of several types of symptoms in individuals with FXS.https://doi.org/10.1002/mgg3.745cognition improvementfragile X syndromemetformintargeted treatment |
| spellingShingle | Dragana Protic Elber Y. Aydin Flora Tassone Maria M. Tan Randi J. Hagerman Andrea Schneider Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases Molecular Genetics & Genomic Medicine cognition improvement fragile X syndrome metformin targeted treatment |
| title | Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases |
| title_full | Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases |
| title_fullStr | Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases |
| title_full_unstemmed | Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases |
| title_short | Cognitive and behavioral improvement in adults with fragile X syndrome treated with metformin‐two cases |
| title_sort | cognitive and behavioral improvement in adults with fragile x syndrome treated with metformin two cases |
| topic | cognition improvement fragile X syndrome metformin targeted treatment |
| url | https://doi.org/10.1002/mgg3.745 |
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