Molecular and Biochemical Techniques for Deciphering p53-MDM2 Regulatory Mechanisms

Molecular and Biochemical Techniques for Deciphering p53-MDM2 Regulatory Mechanisms

The p53 and Mouse double minute 2 (MDM2) proteins are hubs in extensive networks of interactions with multiple partners and functions. Intrinsically disordered regions help to adopt function-specific structural conformations in response to ligand binding and post-translational modifications. Differe...

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Bibliographic Details
Main Authors: Konstantinos Karakostis, Ignacio López, Ana M. Peña-Balderas, Robin Fåhareus, Vanesa Olivares-Illana
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomolecules
Subjects:
protein-protein interactions
protein-RNA interactions
p53 mRNA
MDM2
p53
MDMX
Online Access:https://www.mdpi.com/2218-273X/11/1/36

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