Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity
Recently evolved alleles of Apolipoprotein L-1 (APOL1) provide increased protection against African trypanosome parasites while also significantly increasing the risk of developing kidney disease in humans. APOL1 protects against trypanosome infections by forming ion channels within the parasite, ca...
Main Authors: | Joseph A Giovinazzo, Russell P Thomson, Nailya Khalizova, Patrick J Zager, Nirav Malani, Enrique Rodriguez-Boulan, Jayne Raper, Ryan Schreiner |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-05-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/51185 |
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