Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: A ten-year retrospective study
The diagnosis of systemic onset juvenile idiopathic arthritis (SoJIA) on disease onset is challenging and made mainly by exclusion. This study aimed to investigate the initial clinical and laboratory features of children with SoJIA in Taiwan. Methods: Patients diagnosed with SoJIA at the National Ta...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-10-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664612000538 |
| _version_ | 1824011186069307392 |
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| author | Hu-Yuan Tsai Jyh-Hong Lee Hsin-Hui Yu Li-Chieh Wang Yao-Hsu Yang Bor-Luen Chiang |
| author_facet | Hu-Yuan Tsai Jyh-Hong Lee Hsin-Hui Yu Li-Chieh Wang Yao-Hsu Yang Bor-Luen Chiang |
| author_sort | Hu-Yuan Tsai |
| collection | DOAJ |
| description | The diagnosis of systemic onset juvenile idiopathic arthritis (SoJIA) on disease onset is challenging and made mainly by exclusion. This study aimed to investigate the initial clinical and laboratory features of children with SoJIA in Taiwan.
Methods: Patients diagnosed with SoJIA at the National Taiwan University Hospital between 1997 and 2007 were evaluated and data were collected by retrospective chart review. Inferential statistics were used to compare features of patients with steroid use for <6 months or >6 months.
Results: Twenty-eight (28) patients (13 boys and 15 girls) were included in this study. The mean age of onset was 8.7 years old. The most common presentations were fever (100%), arthritis (89.3%), and skin rash (67.9%). The patterns of arthritis in affected patients were 50% oligoarticular type and 39% polyarticular type. The most common joints involved were the knee (76% of patients with arthritis), ankle (56%), and elbow and proximal interphalangeal joints (28%). The most common pattern of fever during first week was intermittent (53%). Prolonged use of steroid was associated with leukocytosis (17.63±7.71 vs. 11.93±4.43×109 leukocytes/L, p<0.05) and higher aspartate aminotransferase (89.4 vs. 31.2 U/L, p<0.05) on initial presentation.
Conclusion: In SoJIA, extra-articular features such as fever, rash, and lymphadenopathy are most prominent. Leukocytosis and polyarticular pattern on presentation may indicate a refractory clinical course. |
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| format | Article |
| id | doaj.art-1efae696592a414d99e7bd4d58b2a6c5 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-18T21:32:07Z |
| publishDate | 2012-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-1efae696592a414d99e7bd4d58b2a6c52022-12-21T20:51:03ZengElsevierJournal of the Formosan Medical Association0929-66462012-10-011111054254910.1016/j.jfma.2011.06.013Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: A ten-year retrospective studyHu-Yuan TsaiJyh-Hong LeeHsin-Hui YuLi-Chieh WangYao-Hsu YangBor-Luen ChiangThe diagnosis of systemic onset juvenile idiopathic arthritis (SoJIA) on disease onset is challenging and made mainly by exclusion. This study aimed to investigate the initial clinical and laboratory features of children with SoJIA in Taiwan. Methods: Patients diagnosed with SoJIA at the National Taiwan University Hospital between 1997 and 2007 were evaluated and data were collected by retrospective chart review. Inferential statistics were used to compare features of patients with steroid use for <6 months or >6 months. Results: Twenty-eight (28) patients (13 boys and 15 girls) were included in this study. The mean age of onset was 8.7 years old. The most common presentations were fever (100%), arthritis (89.3%), and skin rash (67.9%). The patterns of arthritis in affected patients were 50% oligoarticular type and 39% polyarticular type. The most common joints involved were the knee (76% of patients with arthritis), ankle (56%), and elbow and proximal interphalangeal joints (28%). The most common pattern of fever during first week was intermittent (53%). Prolonged use of steroid was associated with leukocytosis (17.63±7.71 vs. 11.93±4.43×109 leukocytes/L, p<0.05) and higher aspartate aminotransferase (89.4 vs. 31.2 U/L, p<0.05) on initial presentation. Conclusion: In SoJIA, extra-articular features such as fever, rash, and lymphadenopathy are most prominent. Leukocytosis and polyarticular pattern on presentation may indicate a refractory clinical course.http://www.sciencedirect.com/science/article/pii/S0929664612000538systemic juvenile idiopathic arthritissystemic onset juvenile rheumatoid arthritis |
| spellingShingle | Hu-Yuan Tsai Jyh-Hong Lee Hsin-Hui Yu Li-Chieh Wang Yao-Hsu Yang Bor-Luen Chiang Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: A ten-year retrospective study Journal of the Formosan Medical Association systemic juvenile idiopathic arthritis systemic onset juvenile rheumatoid arthritis |
| title | Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: A ten-year retrospective study |
| title_full | Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: A ten-year retrospective study |
| title_fullStr | Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: A ten-year retrospective study |
| title_full_unstemmed | Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: A ten-year retrospective study |
| title_short | Initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis: A ten-year retrospective study |
| title_sort | initial manifestations and clinical course of systemic onset juvenile idiopathic arthritis a ten year retrospective study |
| topic | systemic juvenile idiopathic arthritis systemic onset juvenile rheumatoid arthritis |
| url | http://www.sciencedirect.com/science/article/pii/S0929664612000538 |
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