Inhibition of RNA Helicase Activity Prevents Coxsackievirus B3-Induced Myocarditis in Human iPS Cardiomyocytes

Inhibition of RNA Helicase Activity Prevents Coxsackievirus B3-Induced Myocarditis in Human iPS Cardiomyocytes

Aims: Coxsackievirus B3 (CVB3) is known to be an important cause of myocarditis and dilated cardiomyopathy. Enterovirus-2C (E2C) is a viral RNA helicase. It inhibits host protein synthesis. Based on these facts, we hypothesize that the inhibition of 2C may suppress virus replication and prevent ente...

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Bibliographic Details
Main Authors: Soo-Hyeon Yun, Ha-Hyeon Shin, Eun-Seon Ju, You-Jung Lee, Byung-Kwan Lim, Eun-Seok Jeon
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
coxsackievirus B3
helicase
myocarditis
enterovirus
cardiomyopathy
iPSC
Online Access:https://www.mdpi.com/1422-0067/21/9/3041

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