Protective role of CFTR during fungal infection of cystic fibrosis bronchial epithelial cells with Aspergillus fumigatus

Protective role of CFTR during fungal infection of cystic fibrosis bronchial epithelial cells with Aspergillus fumigatus

Lung infection with the fungus Aspergillus fumigatus (Af) is a common complication in cystic fibrosis (CF) and is associated with loss of pulmonary function. We established a fungal epithelial co-culture model to examine the impact of Af infection on CF bronchial epithelial barrier function using Af...

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Bibliographic Details
Main Authors: Beate Illek, Horst Fischer, Terry E. Machen, Gopika Hari, Karl V. Clemons, Gabriele Sass, Jose A. G. Ferreira, David A. Stevens
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
A. fumigatus conidia
A. fumigatus germlings
A. fumigatus hyphae
gliotoxin
cystic fibrosis
CFTR ion channel
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1196581/full

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