Prominent Intracytoplasmic Crystals in Alveolar Soft Part Sarcoma (ASPS): An Aid in Cytological Diagnosis
Alveolar soft part sarcoma (ASPS) is a rare neoplasm of unknown histogenesis with poor prognosis. Due to the epithelioid appearance of the neoplastic cells, ASPS may resemble many neoplastic conditions, such as metastatic epithelial cell tumours with clear cell change, metastatic renal cell carcin...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-02-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4035/46-%206577_231213_R2_6577_CE[Ra]_PF1(PAK)_PFA(AK)_NEW_PF2(NJH)_BO(NC).pdf |
| _version_ | 1811225603581411328 |
|---|---|
| author | Rahul Mannan Tejinder Singh Bhasin Parampreet Kaur Mridu Manjari Karamjit Singh Gill |
| author_facet | Rahul Mannan Tejinder Singh Bhasin Parampreet Kaur Mridu Manjari Karamjit Singh Gill |
| author_sort | Rahul Mannan |
| collection | DOAJ |
| description | Alveolar soft part sarcoma (ASPS) is a rare neoplasm of unknown histogenesis with poor prognosis. Due to the epithelioid appearance of
the neoplastic cells, ASPS may resemble many neoplastic conditions, such as metastatic epithelial cell tumours with clear cell change,
metastatic renal cell carcinoma, granular cell tumour, epithelioid sarcoma, malignant melanoma and even paragangliomas. Presence of
abundant, rod like crystals in the cytoplasm of tumour cells is an important finding characteristic of this tumour, which helps in differentiating
it from the other entities. The case study highlights the importance of correlating cytological features that help in reaching the diagnosis
such as the background, cell morphology and presence of characteristic rod shaped crystals as immunohistochemical studies are often
non-conclusive. The case also is unique as it demonstrates presence of intra-cytoplamic crystals in such abundance. |
| first_indexed | 2024-04-12T09:10:08Z |
| format | Article |
| id | doaj.art-1effaa0348a7403cb56073d7e8f664ac |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-12T09:10:08Z |
| publishDate | 2014-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-1effaa0348a7403cb56073d7e8f664ac2022-12-22T03:38:59ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-02-018214514610.7860/JCDR/2014/6577.4035Prominent Intracytoplasmic Crystals in Alveolar Soft Part Sarcoma (ASPS): An Aid in Cytological DiagnosisRahul Mannan0Tejinder Singh Bhasin1Parampreet Kaur2Mridu Manjari3Karamjit Singh Gill4Asociate Profesor, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.Professor, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.Resident, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.Professor, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.Professor, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.Alveolar soft part sarcoma (ASPS) is a rare neoplasm of unknown histogenesis with poor prognosis. Due to the epithelioid appearance of the neoplastic cells, ASPS may resemble many neoplastic conditions, such as metastatic epithelial cell tumours with clear cell change, metastatic renal cell carcinoma, granular cell tumour, epithelioid sarcoma, malignant melanoma and even paragangliomas. Presence of abundant, rod like crystals in the cytoplasm of tumour cells is an important finding characteristic of this tumour, which helps in differentiating it from the other entities. The case study highlights the importance of correlating cytological features that help in reaching the diagnosis such as the background, cell morphology and presence of characteristic rod shaped crystals as immunohistochemical studies are often non-conclusive. The case also is unique as it demonstrates presence of intra-cytoplamic crystals in such abundance.https://jcdr.net/articles/PDF/4035/46-%206577_231213_R2_6577_CE[Ra]_PF1(PAK)_PFA(AK)_NEW_PF2(NJH)_BO(NC).pdfintracytoplasmic crystalsalveolar soft part sarcomacytology |
| spellingShingle | Rahul Mannan Tejinder Singh Bhasin Parampreet Kaur Mridu Manjari Karamjit Singh Gill Prominent Intracytoplasmic Crystals in Alveolar Soft Part Sarcoma (ASPS): An Aid in Cytological Diagnosis Journal of Clinical and Diagnostic Research intracytoplasmic crystals alveolar soft part sarcoma cytology |
| title | Prominent Intracytoplasmic Crystals in Alveolar Soft Part Sarcoma (ASPS): An Aid in Cytological Diagnosis |
| title_full | Prominent Intracytoplasmic Crystals in Alveolar Soft Part Sarcoma (ASPS): An Aid in Cytological Diagnosis |
| title_fullStr | Prominent Intracytoplasmic Crystals in Alveolar Soft Part Sarcoma (ASPS): An Aid in Cytological Diagnosis |
| title_full_unstemmed | Prominent Intracytoplasmic Crystals in Alveolar Soft Part Sarcoma (ASPS): An Aid in Cytological Diagnosis |
| title_short | Prominent Intracytoplasmic Crystals in Alveolar Soft Part Sarcoma (ASPS): An Aid in Cytological Diagnosis |
| title_sort | prominent intracytoplasmic crystals in alveolar soft part sarcoma asps an aid in cytological diagnosis |
| topic | intracytoplasmic crystals alveolar soft part sarcoma cytology |
| url | https://jcdr.net/articles/PDF/4035/46-%206577_231213_R2_6577_CE[Ra]_PF1(PAK)_PFA(AK)_NEW_PF2(NJH)_BO(NC).pdf |
| work_keys_str_mv | AT rahulmannan prominentintracytoplasmiccrystalsinalveolarsoftpartsarcomaaspsanaidincytologicaldiagnosis AT tejindersinghbhasin prominentintracytoplasmiccrystalsinalveolarsoftpartsarcomaaspsanaidincytologicaldiagnosis AT parampreetkaur prominentintracytoplasmiccrystalsinalveolarsoftpartsarcomaaspsanaidincytologicaldiagnosis AT mridumanjari prominentintracytoplasmiccrystalsinalveolarsoftpartsarcomaaspsanaidincytologicaldiagnosis AT karamjitsinghgill prominentintracytoplasmiccrystalsinalveolarsoftpartsarcomaaspsanaidincytologicaldiagnosis |