Estimating the role of casual contact from the community in transmission of <it>Bordetella pertussis </it>to young infants
<p>Abstract</p> <p>The proportion of infant pertussis cases due to transmission from casual contact in the community has not been estimated since before the introduction of pertussis vaccines in the 1950s. This study aimed to estimate the proportion of pertussis transmission due to...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-10-01
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| Series: | Emerging Themes in Epidemiology |
| Online Access: | http://www.ete-online.com/content/4/1/15 |
| _version_ | 1819140294053986304 |
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| author | Poole Charles Hudgens Michael G Wendelboe Aaron M Van Rie Annelies |
| author_facet | Poole Charles Hudgens Michael G Wendelboe Aaron M Van Rie Annelies |
| author_sort | Poole Charles |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The proportion of infant pertussis cases due to transmission from casual contact in the community has not been estimated since before the introduction of pertussis vaccines in the 1950s. This study aimed to estimate the proportion of pertussis transmission due to casual contact using demographic and clinical data from a study of 95 infant pertussis cases and their close contacts enrolled at 14 hospitals in France, Germany, Canada, and the U.S. between February 2003 and September 2004. A complete case analysis was conducted as well as multiple imputation (MI) to account for missing data for participants and close contacts who did not participate. By considering all possible close contacts, the MI analysis estimated 66% of source cases were close contacts, implying the minimum attributable proportion of infant cases due to transmission from casual contact with community members was 34% (95% CI = 24%, 44%). Estimates from the complete case analysis were comparable but less precise. Results were sensitive to changes in the operational definition of a source case, which broadened the range of MI point estimates of transmission from casual community contact to 20%–47%. We conclude that casual contact appears to be responsible for a substantial proportion of pertussis transmission to young infants.</p> <p><b>Medical subject headings (MeSH): </b>multiple imputation, pertussis, transmission, casual contact, sensitivity analysis, missing data, community.</p> |
| first_indexed | 2024-12-22T11:36:16Z |
| format | Article |
| id | doaj.art-1effbf750c3844838801aaf39323088c |
| institution | Directory Open Access Journal |
| issn | 1742-7622 |
| language | English |
| last_indexed | 2024-12-22T11:36:16Z |
| publishDate | 2007-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Emerging Themes in Epidemiology |
| spelling | doaj.art-1effbf750c3844838801aaf39323088c2022-12-21T18:27:26ZengBMCEmerging Themes in Epidemiology1742-76222007-10-01411510.1186/1742-7622-4-15Estimating the role of casual contact from the community in transmission of <it>Bordetella pertussis </it>to young infantsPoole CharlesHudgens Michael GWendelboe Aaron MVan Rie Annelies<p>Abstract</p> <p>The proportion of infant pertussis cases due to transmission from casual contact in the community has not been estimated since before the introduction of pertussis vaccines in the 1950s. This study aimed to estimate the proportion of pertussis transmission due to casual contact using demographic and clinical data from a study of 95 infant pertussis cases and their close contacts enrolled at 14 hospitals in France, Germany, Canada, and the U.S. between February 2003 and September 2004. A complete case analysis was conducted as well as multiple imputation (MI) to account for missing data for participants and close contacts who did not participate. By considering all possible close contacts, the MI analysis estimated 66% of source cases were close contacts, implying the minimum attributable proportion of infant cases due to transmission from casual contact with community members was 34% (95% CI = 24%, 44%). Estimates from the complete case analysis were comparable but less precise. Results were sensitive to changes in the operational definition of a source case, which broadened the range of MI point estimates of transmission from casual community contact to 20%–47%. We conclude that casual contact appears to be responsible for a substantial proportion of pertussis transmission to young infants.</p> <p><b>Medical subject headings (MeSH): </b>multiple imputation, pertussis, transmission, casual contact, sensitivity analysis, missing data, community.</p>http://www.ete-online.com/content/4/1/15 |
| spellingShingle | Poole Charles Hudgens Michael G Wendelboe Aaron M Van Rie Annelies Estimating the role of casual contact from the community in transmission of <it>Bordetella pertussis </it>to young infants Emerging Themes in Epidemiology |
| title | Estimating the role of casual contact from the community in transmission of <it>Bordetella pertussis </it>to young infants |
| title_full | Estimating the role of casual contact from the community in transmission of <it>Bordetella pertussis </it>to young infants |
| title_fullStr | Estimating the role of casual contact from the community in transmission of <it>Bordetella pertussis </it>to young infants |
| title_full_unstemmed | Estimating the role of casual contact from the community in transmission of <it>Bordetella pertussis </it>to young infants |
| title_short | Estimating the role of casual contact from the community in transmission of <it>Bordetella pertussis </it>to young infants |
| title_sort | estimating the role of casual contact from the community in transmission of it bordetella pertussis it to young infants |
| url | http://www.ete-online.com/content/4/1/15 |
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