267 Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes anti-tumor immunity and improves therapeutic window

Bibliographic Details
Main Authors: Shahram Salek-Ardakani, Wenjing Yang, Sheng Ding, Shih-Hsun Chen, Jessica Stanfield, Nadia Kurd, Ryan Llewellyn, Jonathan Heyen, Carole Wang, Zea Melton, Javier Chaparro-Riggers, Pawel Dominik, Kevin Lindquist, Thomas Van Blarcom
Format: Article
Language:English
Published: BMJ Publishing Group 2021-11-01
Series:Journal for ImmunoTherapy of Cancer
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author Shahram Salek-Ardakani
Wenjing Yang
Sheng Ding
Shih-Hsun Chen
Jessica Stanfield
Nadia Kurd
Ryan Llewellyn
Jonathan Heyen
Carole Wang
Zea Melton
Javier Chaparro-Riggers
Pawel Dominik
Kevin Lindquist
Thomas Van Blarcom
author_facet Shahram Salek-Ardakani
Wenjing Yang
Sheng Ding
Shih-Hsun Chen
Jessica Stanfield
Nadia Kurd
Ryan Llewellyn
Jonathan Heyen
Carole Wang
Zea Melton
Javier Chaparro-Riggers
Pawel Dominik
Kevin Lindquist
Thomas Van Blarcom
author_sort Shahram Salek-Ardakani
collection DOAJ
first_indexed 2024-12-22T22:26:05Z
format Article
id doaj.art-1f019c3519b849a08123380e84c26521
institution Directory Open Access Journal
issn 2051-1426
language English
last_indexed 2024-12-22T22:26:05Z
publishDate 2021-11-01
publisher BMJ Publishing Group
record_format Article
series Journal for ImmunoTherapy of Cancer
spelling doaj.art-1f019c3519b849a08123380e84c265212022-12-21T18:10:33ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262021-11-019Suppl 210.1136/jitc-2021-SITC2021.267267 Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes anti-tumor immunity and improves therapeutic windowShahram Salek-Ardakani0Wenjing Yang1Sheng Ding2Shih-Hsun Chen3Jessica Stanfield4Nadia Kurd5Ryan Llewellyn6Jonathan Heyen7Carole Wang8Zea Melton9Javier Chaparro-Riggers10Pawel Dominik11Kevin Lindquist12Thomas Van Blarcom13Cancer Immunology Discovery, Pfizer Inc, San Diego, California, USAComputational Biology, Pfizer Inc, San Diego, California, USABioMedicine Design, Pfizer Inc, San Diego, California, USACancer Immunology Discovery, Pfizer Inc, San Diego, California, USACancer Immunology Discovery, Pfizer Inc, San Diego, California, USACancer Immunology Discovery, Pfizer Inc, San Diego, California, USACancer Immunology Discovery, Pfizer Inc, San Diego, California, USADrug Safety R&D, Pfizer Inc, San Diego, California, USABioMedicine Design, Pfizer Inc, San Diego, California, USABioMedicine Design, Pfizer Inc, San Diego, California, USABioMedicine Design, Pfizer Inc, San Diego, California, USAPfizer, San Diego, CA, USAPfizer, San Diego, CA, USAPfizer, San Diego, CA, USA
spellingShingle Shahram Salek-Ardakani
Wenjing Yang
Sheng Ding
Shih-Hsun Chen
Jessica Stanfield
Nadia Kurd
Ryan Llewellyn
Jonathan Heyen
Carole Wang
Zea Melton
Javier Chaparro-Riggers
Pawel Dominik
Kevin Lindquist
Thomas Van Blarcom
267 Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes anti-tumor immunity and improves therapeutic window
Journal for ImmunoTherapy of Cancer
title 267 Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes anti-tumor immunity and improves therapeutic window
title_full 267 Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes anti-tumor immunity and improves therapeutic window
title_fullStr 267 Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes anti-tumor immunity and improves therapeutic window
title_full_unstemmed 267 Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes anti-tumor immunity and improves therapeutic window
title_short 267 Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes anti-tumor immunity and improves therapeutic window
title_sort 267 dual checkpoint blockade of cd47 and pd l1 using an affinity tuned bispecific antibody maximizes anti tumor immunity and improves therapeutic window
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AT wenjingyang 267dualcheckpointblockadeofcd47andpdl1usinganaffinitytunedbispecificantibodymaximizesantitumorimmunityandimprovestherapeuticwindow
AT shengding 267dualcheckpointblockadeofcd47andpdl1usinganaffinitytunedbispecificantibodymaximizesantitumorimmunityandimprovestherapeuticwindow
AT shihhsunchen 267dualcheckpointblockadeofcd47andpdl1usinganaffinitytunedbispecificantibodymaximizesantitumorimmunityandimprovestherapeuticwindow
AT jessicastanfield 267dualcheckpointblockadeofcd47andpdl1usinganaffinitytunedbispecificantibodymaximizesantitumorimmunityandimprovestherapeuticwindow
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AT jonathanheyen 267dualcheckpointblockadeofcd47andpdl1usinganaffinitytunedbispecificantibodymaximizesantitumorimmunityandimprovestherapeuticwindow
AT carolewang 267dualcheckpointblockadeofcd47andpdl1usinganaffinitytunedbispecificantibodymaximizesantitumorimmunityandimprovestherapeuticwindow
AT zeamelton 267dualcheckpointblockadeofcd47andpdl1usinganaffinitytunedbispecificantibodymaximizesantitumorimmunityandimprovestherapeuticwindow
AT javierchaparroriggers 267dualcheckpointblockadeofcd47andpdl1usinganaffinitytunedbispecificantibodymaximizesantitumorimmunityandimprovestherapeuticwindow
AT paweldominik 267dualcheckpointblockadeofcd47andpdl1usinganaffinitytunedbispecificantibodymaximizesantitumorimmunityandimprovestherapeuticwindow
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AT thomasvanblarcom 267dualcheckpointblockadeofcd47andpdl1usinganaffinitytunedbispecificantibodymaximizesantitumorimmunityandimprovestherapeuticwindow