Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications
Abstract The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of components, including immune cells and stromal cells, that exert a profound influence on tumor initiation and progression. Within the TME, angiogenesis is predominantly orchestrated by endothelial cells...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-09-01
|
| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-023-06119-x |
| _version_ | 1797689018670907392 |
|---|---|
| author | Jianwen Fang Yue Lu Jingyan Zheng Xiaocong Jiang Haixing Shen Xi Shang Yuexin Lu Peifen Fu |
| author_facet | Jianwen Fang Yue Lu Jingyan Zheng Xiaocong Jiang Haixing Shen Xi Shang Yuexin Lu Peifen Fu |
| author_sort | Jianwen Fang |
| collection | DOAJ |
| description | Abstract The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of components, including immune cells and stromal cells, that exert a profound influence on tumor initiation and progression. Within the TME, angiogenesis is predominantly orchestrated by endothelial cells (ECs), which foster the proliferation and metastasis of malignant cells. The interplay between tumor and immune cells with ECs is complex and can either bolster or hinder the immune system. Thus, a comprehensive understanding of the intricate crosstalk between ECs and immune cells is essential to advance the development of immunotherapeutic interventions. Despite recent progress, the underlying molecular mechanisms that govern the interplay between ECs and immune cells remain elusive. Nevertheless, the immunomodulatory function of ECs has emerged as a pivotal determinant of the immune response. In light of this, the study of the relationship between ECs and immune checkpoints has garnered considerable attention in the field of immunotherapy. By targeting specific molecular pathways and signaling molecules associated with ECs in the TME, novel immunotherapeutic strategies may be devised to enhance the efficacy of current treatments. In this vein, we sought to elucidate the relationship between ECs, immune cells, and immune checkpoints in the TME, with the ultimate goal of identifying novel therapeutic targets and charting new avenues for immunotherapy. |
| first_indexed | 2024-03-12T01:40:53Z |
| format | Article |
| id | doaj.art-1f0241f173e84a66ae639d859cb6abb6 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-03-12T01:40:53Z |
| publishDate | 2023-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-1f0241f173e84a66ae639d859cb6abb62023-09-10T11:28:11ZengNature Publishing GroupCell Death and Disease2041-48892023-09-0114911510.1038/s41419-023-06119-xExploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implicationsJianwen Fang0Yue Lu1Jingyan Zheng2Xiaocong Jiang3Haixing Shen4Xi Shang5Yuexin Lu6Peifen Fu7Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Breast and Thyroid Surgery, First Affiliated Hospital of Huzhou UniversityDepartment of Breast and Thyroid Surgery, Lishui People’s Hospital, The Six Affiliated Hospital of Wenzhou Medical UniversityDepartment of Breast Surgery, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Breast Surgery, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Breast and Thyroid Surgery, Taizhou Hospital, Zhejiang UniversityDepartment of Breast Surgery, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Breast Surgery, The First Affiliated Hospital, Zhejiang University School of MedicineAbstract The tumor microenvironment (TME) is a highly intricate milieu, comprising a multitude of components, including immune cells and stromal cells, that exert a profound influence on tumor initiation and progression. Within the TME, angiogenesis is predominantly orchestrated by endothelial cells (ECs), which foster the proliferation and metastasis of malignant cells. The interplay between tumor and immune cells with ECs is complex and can either bolster or hinder the immune system. Thus, a comprehensive understanding of the intricate crosstalk between ECs and immune cells is essential to advance the development of immunotherapeutic interventions. Despite recent progress, the underlying molecular mechanisms that govern the interplay between ECs and immune cells remain elusive. Nevertheless, the immunomodulatory function of ECs has emerged as a pivotal determinant of the immune response. In light of this, the study of the relationship between ECs and immune checkpoints has garnered considerable attention in the field of immunotherapy. By targeting specific molecular pathways and signaling molecules associated with ECs in the TME, novel immunotherapeutic strategies may be devised to enhance the efficacy of current treatments. In this vein, we sought to elucidate the relationship between ECs, immune cells, and immune checkpoints in the TME, with the ultimate goal of identifying novel therapeutic targets and charting new avenues for immunotherapy.https://doi.org/10.1038/s41419-023-06119-x |
| spellingShingle | Jianwen Fang Yue Lu Jingyan Zheng Xiaocong Jiang Haixing Shen Xi Shang Yuexin Lu Peifen Fu Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications Cell Death and Disease |
| title | Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications |
| title_full | Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications |
| title_fullStr | Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications |
| title_full_unstemmed | Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications |
| title_short | Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications |
| title_sort | exploring the crosstalk between endothelial cells immune cells and immune checkpoints in the tumor microenvironment new insights and therapeutic implications |
| url | https://doi.org/10.1038/s41419-023-06119-x |
| work_keys_str_mv | AT jianwenfang exploringthecrosstalkbetweenendothelialcellsimmunecellsandimmunecheckpointsinthetumormicroenvironmentnewinsightsandtherapeuticimplications AT yuelu exploringthecrosstalkbetweenendothelialcellsimmunecellsandimmunecheckpointsinthetumormicroenvironmentnewinsightsandtherapeuticimplications AT jingyanzheng exploringthecrosstalkbetweenendothelialcellsimmunecellsandimmunecheckpointsinthetumormicroenvironmentnewinsightsandtherapeuticimplications AT xiaocongjiang exploringthecrosstalkbetweenendothelialcellsimmunecellsandimmunecheckpointsinthetumormicroenvironmentnewinsightsandtherapeuticimplications AT haixingshen exploringthecrosstalkbetweenendothelialcellsimmunecellsandimmunecheckpointsinthetumormicroenvironmentnewinsightsandtherapeuticimplications AT xishang exploringthecrosstalkbetweenendothelialcellsimmunecellsandimmunecheckpointsinthetumormicroenvironmentnewinsightsandtherapeuticimplications AT yuexinlu exploringthecrosstalkbetweenendothelialcellsimmunecellsandimmunecheckpointsinthetumormicroenvironmentnewinsightsandtherapeuticimplications AT peifenfu exploringthecrosstalkbetweenendothelialcellsimmunecellsandimmunecheckpointsinthetumormicroenvironmentnewinsightsandtherapeuticimplications |