Effects of Grape Seed Extract Supplementation on Fasting Blood Glucose, Insulin Resistance, and Lipid Profile in Women With Polycystic Ovary Syndrome
Introduction: This research aimed to examine the impact of Grape Seed Extract (GSE) supplementation on fasting blood glucose level, insulin resistance, and serum lipid profile in women with Polycystic Ovary Syndrome (PCOS). Methods: Fifty individuals with and without PCOS were selected (GSE=25, &am...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Negah Institute for Scientific Communication
2020-08-01
|
| Series: | Anatomical Sciences Journal |
| Subjects: | |
| Online Access: | http://anatomyjournal.ir/article-1-267-en.html |
| _version_ | 1811334988151390208 |
|---|---|
| author | Pegah Sedighi Bijan Helli Asaad Sharhani Afkham Vatanpur |
| author_facet | Pegah Sedighi Bijan Helli Asaad Sharhani Afkham Vatanpur |
| author_sort | Pegah Sedighi |
| collection | DOAJ |
| description | Introduction: This research aimed to examine the impact of Grape Seed Extract (GSE) supplementation on fasting blood glucose level, insulin resistance, and serum lipid profile in women with Polycystic Ovary Syndrome (PCOS).
Methods: Fifty individuals with and without PCOS were selected (GSE=25, & placebo=25) as the study participants. They received 400 mg/d of GSE (in the form of capsules) or placebo for 8 weeks. The samples of fasting blood glucose were collected in two stages of the beginning and end of the treatment. Total Cholesterol (TC), Low-Density Lipoprotein (LDL), Triglycerides (TG), Insulin-Resistance Homeostatic Model Assessment (HOMA-IR), and High-Density Lipoprotein (HDL) were measured biochemically. For statistical analysis, Independent Samples t-test, Paired Samples t-test, and Analysis of Covariance (ANCOVA) were used.
Results: GSE supplementation declined the levels of serum fasting blood glucose, insulin, HOMA-IR, TC, LDL, and weight. Additionally, HDL was elevated in the test group, compared to the controls (P<0.05). In comparison with the baseline values, the serum HOMA-IR and FBS levels were significantly decreased (P=0.005 & P=0.02, respectively). Besides, serum insulin level was increased in the GSE group. In the GSE group, the TG and Body Mass Index (BMI) were lower than the baseline values. In either category, no significant changes were detected in serum TC and LDL-C levels.
Conclusion: Short-term GSE therapy provided beneficial therapeutic impacts on PCOS-positive women’s metabolic status (e.g., HOMA-IR); thus, this approach could be effective in PCOS complications management. |
| first_indexed | 2024-04-13T17:17:18Z |
| format | Article |
| id | doaj.art-1f049028c5704be1b7c5d34745600ecc |
| institution | Directory Open Access Journal |
| issn | 2322-3626 |
| language | English |
| last_indexed | 2024-04-13T17:17:18Z |
| publishDate | 2020-08-01 |
| publisher | Negah Institute for Scientific Communication |
| record_format | Article |
| series | Anatomical Sciences Journal |
| spelling | doaj.art-1f049028c5704be1b7c5d34745600ecc2022-12-22T02:38:06ZengNegah Institute for Scientific CommunicationAnatomical Sciences Journal2322-36262020-08-011727382Effects of Grape Seed Extract Supplementation on Fasting Blood Glucose, Insulin Resistance, and Lipid Profile in Women With Polycystic Ovary SyndromePegah Sedighi0Bijan Helli1Asaad Sharhani2Afkham Vatanpur3 Nutrition and Metabolic Diseases Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Nutrition and Metabolic Diseases Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran, Department of Nutrition, School of Allied Medical Sciences, Jundishapur University of Medical Sciences, Ahvaz, Iran, Department of Nutrition,Iranian Social Security Organization, Tehran, Iran. Department of Epidemiology and Biostatistics School of Public Health, Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Gynaecology,Iranian Social Security Organization, Tehran, Iran. Introduction: This research aimed to examine the impact of Grape Seed Extract (GSE) supplementation on fasting blood glucose level, insulin resistance, and serum lipid profile in women with Polycystic Ovary Syndrome (PCOS). Methods: Fifty individuals with and without PCOS were selected (GSE=25, & placebo=25) as the study participants. They received 400 mg/d of GSE (in the form of capsules) or placebo for 8 weeks. The samples of fasting blood glucose were collected in two stages of the beginning and end of the treatment. Total Cholesterol (TC), Low-Density Lipoprotein (LDL), Triglycerides (TG), Insulin-Resistance Homeostatic Model Assessment (HOMA-IR), and High-Density Lipoprotein (HDL) were measured biochemically. For statistical analysis, Independent Samples t-test, Paired Samples t-test, and Analysis of Covariance (ANCOVA) were used. Results: GSE supplementation declined the levels of serum fasting blood glucose, insulin, HOMA-IR, TC, LDL, and weight. Additionally, HDL was elevated in the test group, compared to the controls (P<0.05). In comparison with the baseline values, the serum HOMA-IR and FBS levels were significantly decreased (P=0.005 & P=0.02, respectively). Besides, serum insulin level was increased in the GSE group. In the GSE group, the TG and Body Mass Index (BMI) were lower than the baseline values. In either category, no significant changes were detected in serum TC and LDL-C levels. Conclusion: Short-term GSE therapy provided beneficial therapeutic impacts on PCOS-positive women’s metabolic status (e.g., HOMA-IR); thus, this approach could be effective in PCOS complications management.http://anatomyjournal.ir/article-1-267-en.htmlpolycystic ovary syndromelow-density lipoproteingrape seed extractcholestero |
| spellingShingle | Pegah Sedighi Bijan Helli Asaad Sharhani Afkham Vatanpur Effects of Grape Seed Extract Supplementation on Fasting Blood Glucose, Insulin Resistance, and Lipid Profile in Women With Polycystic Ovary Syndrome Anatomical Sciences Journal polycystic ovary syndrome low-density lipoprotein grape seed extract cholestero |
| title | Effects of Grape Seed Extract Supplementation on Fasting Blood Glucose, Insulin Resistance, and Lipid Profile in Women With Polycystic Ovary Syndrome |
| title_full | Effects of Grape Seed Extract Supplementation on Fasting Blood Glucose, Insulin Resistance, and Lipid Profile in Women With Polycystic Ovary Syndrome |
| title_fullStr | Effects of Grape Seed Extract Supplementation on Fasting Blood Glucose, Insulin Resistance, and Lipid Profile in Women With Polycystic Ovary Syndrome |
| title_full_unstemmed | Effects of Grape Seed Extract Supplementation on Fasting Blood Glucose, Insulin Resistance, and Lipid Profile in Women With Polycystic Ovary Syndrome |
| title_short | Effects of Grape Seed Extract Supplementation on Fasting Blood Glucose, Insulin Resistance, and Lipid Profile in Women With Polycystic Ovary Syndrome |
| title_sort | effects of grape seed extract supplementation on fasting blood glucose insulin resistance and lipid profile in women with polycystic ovary syndrome |
| topic | polycystic ovary syndrome low-density lipoprotein grape seed extract cholestero |
| url | http://anatomyjournal.ir/article-1-267-en.html |
| work_keys_str_mv | AT pegahsedighi effectsofgrapeseedextractsupplementationonfastingbloodglucoseinsulinresistanceandlipidprofileinwomenwithpolycysticovarysyndrome AT bijanhelli effectsofgrapeseedextractsupplementationonfastingbloodglucoseinsulinresistanceandlipidprofileinwomenwithpolycysticovarysyndrome AT asaadsharhani effectsofgrapeseedextractsupplementationonfastingbloodglucoseinsulinresistanceandlipidprofileinwomenwithpolycysticovarysyndrome AT afkhamvatanpur effectsofgrapeseedextractsupplementationonfastingbloodglucoseinsulinresistanceandlipidprofileinwomenwithpolycysticovarysyndrome |