Study of The Protective Effect of Garlic Water Extract on Dexamethasone-Induced Hepatotoxicity and Insulin Resistance in Adult Male Albino Rats
Background: The liver has an essential role in the metabolism and detoxification of various metabolites and drugs so it is liable to injury. Long-term use of dexamethasone may cause hepatic injury and insulin resistance. Garlic contains a variety of effective compounds that exhibit antioxidant, hypo...
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| Format: | Article |
| Language: | English |
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Al-Azhar University, Faculty of Medicine (Damietta)
2022-08-01
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| Series: | International Journal of Medical Arts |
| Subjects: | |
| Online Access: | https://ijma.journals.ekb.eg/article_272775_38feb58949a7f068bcc8a6d609ea0243.pdf |
| _version_ | 1797364417489272832 |
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| author | Ahmad Alkot Suhaib Naeem Said El Sayed Ashraf Algendy Mohamed Hablas |
| author_facet | Ahmad Alkot Suhaib Naeem Said El Sayed Ashraf Algendy Mohamed Hablas |
| author_sort | Ahmad Alkot |
| collection | DOAJ |
| description | Background: The liver has an essential role in the metabolism and detoxification of various metabolites and drugs so it is liable to injury. Long-term use of dexamethasone may cause hepatic injury and insulin resistance. Garlic contains a variety of effective compounds that exhibit antioxidant, hypo-cholesterolemic, hypoglycemic, antithrombotic, antibiotic, anticancer, as well as hypotensive activities.Objective: To study the effect of garlic water extract on hepatic toxicity and insulin resistance induced by dexamethasone in adult male albino rats.Materials and Methods: Twenty-four adult male albino rats of a local strain were divided into three equal groups, group 1 [control group], group 2 [dexamethasone-treated group], and group 3 [dexamethasone and garlic-treated group]. After two weeks from the onset of the experiment serum was isolated from blood samples for assessment of Alanine Transaminase [ALT], Aspartate Transaminase [AST], serum albumin, Alkaline Phosphatase [ALP], total bilirubin, fasting blood glucose [FBG], and Fasting insulin level. Homeostasis Model Assessment for Insulin Resistance [HOMA-IR] was then calculated. Samples of the liver were taken for histopathological studies.Results: There was a significant elevation in ALT, AST, ALP, and total bilirubin and a significant reduction in serum albumin in the dexamethasone-treated group when compared with the control group. ALT, AST, ALP, and total bilirubin significantly improved in the dexamethasone and garlic extract-treated group. Also, there was a significant elevation in FBS, insulin level, and HOMA-IR in the dexamethasone-treated group when compared with the control group. These parameters were significantly decreased in the dexamethasone and garlic extract-treated group when compared with the dexamethasone-only treated group.Conclusion: Garlic water extract showed a potential protective effect against dexamethasone-induced liver injury and insulin resistance. |
| first_indexed | 2024-03-08T16:35:01Z |
| format | Article |
| id | doaj.art-1f077d9187fe4691acf60eb772b4a503 |
| institution | Directory Open Access Journal |
| issn | 2636-4174 2682-3780 |
| language | English |
| last_indexed | 2024-03-08T16:35:01Z |
| publishDate | 2022-08-01 |
| publisher | Al-Azhar University, Faculty of Medicine (Damietta) |
| record_format | Article |
| series | International Journal of Medical Arts |
| spelling | doaj.art-1f077d9187fe4691acf60eb772b4a5032024-01-05T19:38:50ZengAl-Azhar University, Faculty of Medicine (Damietta)International Journal of Medical Arts2636-41742682-37802022-08-01482606261810.21608/ijma.2022.172037.1539272775Study of The Protective Effect of Garlic Water Extract on Dexamethasone-Induced Hepatotoxicity and Insulin Resistance in Adult Male Albino RatsAhmad Alkot0Suhaib Naeem1Said El Sayed2Ashraf Algendy3Mohamed Hablas4Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, Cairo, EgyptDepartment of Histology, Faculty of Medicine, Al-Azhar University, Cairo, EgyptDepartment of Medical Physiology, Faculty of Medicine, Al-Azhar University, Cairo, EgyptDepartment of Medical Physiology, Faculty of Medicine, Al-Azhar University, Cairo, EgyptDepartment of Histology, Faculty of Medicine [Assiut], Al-Azhar University, Assiut, EgyptBackground: The liver has an essential role in the metabolism and detoxification of various metabolites and drugs so it is liable to injury. Long-term use of dexamethasone may cause hepatic injury and insulin resistance. Garlic contains a variety of effective compounds that exhibit antioxidant, hypo-cholesterolemic, hypoglycemic, antithrombotic, antibiotic, anticancer, as well as hypotensive activities.Objective: To study the effect of garlic water extract on hepatic toxicity and insulin resistance induced by dexamethasone in adult male albino rats.Materials and Methods: Twenty-four adult male albino rats of a local strain were divided into three equal groups, group 1 [control group], group 2 [dexamethasone-treated group], and group 3 [dexamethasone and garlic-treated group]. After two weeks from the onset of the experiment serum was isolated from blood samples for assessment of Alanine Transaminase [ALT], Aspartate Transaminase [AST], serum albumin, Alkaline Phosphatase [ALP], total bilirubin, fasting blood glucose [FBG], and Fasting insulin level. Homeostasis Model Assessment for Insulin Resistance [HOMA-IR] was then calculated. Samples of the liver were taken for histopathological studies.Results: There was a significant elevation in ALT, AST, ALP, and total bilirubin and a significant reduction in serum albumin in the dexamethasone-treated group when compared with the control group. ALT, AST, ALP, and total bilirubin significantly improved in the dexamethasone and garlic extract-treated group. Also, there was a significant elevation in FBS, insulin level, and HOMA-IR in the dexamethasone-treated group when compared with the control group. These parameters were significantly decreased in the dexamethasone and garlic extract-treated group when compared with the dexamethasone-only treated group.Conclusion: Garlic water extract showed a potential protective effect against dexamethasone-induced liver injury and insulin resistance.https://ijma.journals.ekb.eg/article_272775_38feb58949a7f068bcc8a6d609ea0243.pdfgarlic water extractdexamethasonehepatotoxicityinsulin resistance |
| spellingShingle | Ahmad Alkot Suhaib Naeem Said El Sayed Ashraf Algendy Mohamed Hablas Study of The Protective Effect of Garlic Water Extract on Dexamethasone-Induced Hepatotoxicity and Insulin Resistance in Adult Male Albino Rats International Journal of Medical Arts garlic water extract dexamethasone hepatotoxicity insulin resistance |
| title | Study of The Protective Effect of Garlic Water Extract on Dexamethasone-Induced Hepatotoxicity and Insulin Resistance in Adult Male Albino Rats |
| title_full | Study of The Protective Effect of Garlic Water Extract on Dexamethasone-Induced Hepatotoxicity and Insulin Resistance in Adult Male Albino Rats |
| title_fullStr | Study of The Protective Effect of Garlic Water Extract on Dexamethasone-Induced Hepatotoxicity and Insulin Resistance in Adult Male Albino Rats |
| title_full_unstemmed | Study of The Protective Effect of Garlic Water Extract on Dexamethasone-Induced Hepatotoxicity and Insulin Resistance in Adult Male Albino Rats |
| title_short | Study of The Protective Effect of Garlic Water Extract on Dexamethasone-Induced Hepatotoxicity and Insulin Resistance in Adult Male Albino Rats |
| title_sort | study of the protective effect of garlic water extract on dexamethasone induced hepatotoxicity and insulin resistance in adult male albino rats |
| topic | garlic water extract dexamethasone hepatotoxicity insulin resistance |
| url | https://ijma.journals.ekb.eg/article_272775_38feb58949a7f068bcc8a6d609ea0243.pdf |
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