Therapeutic efficacy of humanized monoclonal antibodies targeting dengue virus nonstructural protein 1 in the mouse model.

Therapeutic efficacy of humanized monoclonal antibodies targeting dengue virus nonstructural protein 1 in the mouse model.

Dengue virus (DENV) which infects about 390 million people per year in tropical and subtropical areas manifests various disease symptoms, ranging from fever to life-threatening hemorrhage and even shock. To date, there is still no effective treatment for DENV disease, but only supportive care. DENV...

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Bibliographic Details
Main Authors: Sen-Mao Tien, Po-Chun Chang, Yen-Chung Lai, Yung-Chun Chuang, Chin-Kai Tseng, Yu-San Kao, Hong-Jyun Huang, Yu-Peng Hsiao, Yi-Ling Liu, Hsing-Han Lin, Chien-Chou Chu, Miao-Huei Cheng, Tzong-Shiann Ho, Chih-Peng Chang, Shu-Fen Ko, Che-Piao Shen, Robert Anderson, Yee-Shin Lin, Shu-Wen Wan, Trai-Ming Yeh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010469

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