Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6–HMGB1 deacetylation
Abstract Background Vascular calcification associated with chronic kidney disease (CKD) can increase the risk of mortality. Elevated serum levels of high mobility group box 1 (HMGB1) promotes vascular calcification in CKD via the Wnt/β-catenin pathway. Sirtuin 6 (SIRT6) prevents fibrosis in CKD by b...
| Príomhchruthaitheoirí: | , , , , , , |
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| Formáid: | Alt |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
BMC
2021-04-01
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| Sraith: | Stem Cell Research & Therapy |
| Ábhair: | |
| Rochtain ar líne: | https://doi.org/10.1186/s13287-021-02307-8 |