Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6–HMGB1 deacetylation

Bone marrow mesenchymal stem cell exosomes suppress phosphate-induced aortic calcification via SIRT6–HMGB1 deacetylation

Abstract Background Vascular calcification associated with chronic kidney disease (CKD) can increase the risk of mortality. Elevated serum levels of high mobility group box 1 (HMGB1) promotes vascular calcification in CKD via the Wnt/β-catenin pathway. Sirtuin 6 (SIRT6) prevents fibrosis in CKD by b...

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Bibliographic Details
Main Authors: Wenqian Wei, Xiaodong Guo, Lijie Gu, Jieshuang Jia, Man Yang, Weijie Yuan, Shu Rong
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Stem Cell Research & Therapy
Subjects:
Chronic kidney disease
Vascular calcification
Bone marrow mesenchymal stem cells
Exosomes
SIRT6
HMGB1
Online Access:https://doi.org/10.1186/s13287-021-02307-8

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