Effects of Different Ratios of Carbohydrate–Fat in Enteral Nutrition on Metabolic Pattern and Organ Damage in Burned Rats
(1) Background: Nutritional support is one of the most important cornerstones in the management of patients with severe burns, but the carbohydrate-to-fat ratios in burn nutrition therapy remain highly controversial. In this study, we aimed to discuss the effects of different ratios of carbohydrate–...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/17/3653 |
| _version_ | 1797493686384197632 |
|---|---|
| author | Yongjun Yang Sen Su Yong Zhang Dan Wu Chao Wang Yan Wei Xi Peng |
| author_facet | Yongjun Yang Sen Su Yong Zhang Dan Wu Chao Wang Yan Wei Xi Peng |
| author_sort | Yongjun Yang |
| collection | DOAJ |
| description | (1) Background: Nutritional support is one of the most important cornerstones in the management of patients with severe burns, but the carbohydrate-to-fat ratios in burn nutrition therapy remain highly controversial. In this study, we aimed to discuss the effects of different ratios of carbohydrate–fat through enteral nutrition on the metabolic changes and organ damage in burned rats. (2) Methods: Twenty-four burned rats were randomly divided into 5%, 10%, 20% and 30% fat nutritional groups. REE and body weight were measured individually for each rat daily. Then, 75% of REE was given in the first week after burns, and the full dose was given in the second week. Glucose tolerance of the rats was measured on days 1, 3, 7, 10 and 14. Blood biochemistry analysis and organ damage analysis were performed after 7 and 14 days of nutritional therapy, and nuclear magnetic resonance (NMR) and insulin content analysis were performed after 14 days. (3) Results: NMR spectra showed significant differences of glucose, lipid and amino acid metabolic pathways. The energy expenditure increased, and body weight decreased significantly after burn injury, with larger change in the 20%, 5% and 30% fat groups, and minimal change in the 10% fat group. The obvious changes in the level of plasma protein, glucose, lipids and insulin, as well as the organ damage, were in the 30%, 20% and 5% fat groups. In relative terms, the 10% fat group showed the least variation and was closest to normal group. (4) Conclusion: Lower fat intake is beneficial to maintaining metabolic stability and lessening organ damage after burns, but percentage of fat supply should not be less than 10% in burned rats. |
| first_indexed | 2024-03-10T01:23:36Z |
| format | Article |
| id | doaj.art-1f0a386a9ee1438e87ee106ec2928fb2 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:23:36Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-1f0a386a9ee1438e87ee106ec2928fb22023-11-23T13:54:09ZengMDPI AGNutrients2072-66432022-09-011417365310.3390/nu14173653Effects of Different Ratios of Carbohydrate–Fat in Enteral Nutrition on Metabolic Pattern and Organ Damage in Burned RatsYongjun Yang0Sen Su1Yong Zhang2Dan Wu3Chao Wang4Yan Wei5Xi Peng6Clinical Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, ChinaClinical Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, ChinaClinical Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, ChinaClinical Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, ChinaClinical Medical Research Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China(1) Background: Nutritional support is one of the most important cornerstones in the management of patients with severe burns, but the carbohydrate-to-fat ratios in burn nutrition therapy remain highly controversial. In this study, we aimed to discuss the effects of different ratios of carbohydrate–fat through enteral nutrition on the metabolic changes and organ damage in burned rats. (2) Methods: Twenty-four burned rats were randomly divided into 5%, 10%, 20% and 30% fat nutritional groups. REE and body weight were measured individually for each rat daily. Then, 75% of REE was given in the first week after burns, and the full dose was given in the second week. Glucose tolerance of the rats was measured on days 1, 3, 7, 10 and 14. Blood biochemistry analysis and organ damage analysis were performed after 7 and 14 days of nutritional therapy, and nuclear magnetic resonance (NMR) and insulin content analysis were performed after 14 days. (3) Results: NMR spectra showed significant differences of glucose, lipid and amino acid metabolic pathways. The energy expenditure increased, and body weight decreased significantly after burn injury, with larger change in the 20%, 5% and 30% fat groups, and minimal change in the 10% fat group. The obvious changes in the level of plasma protein, glucose, lipids and insulin, as well as the organ damage, were in the 30%, 20% and 5% fat groups. In relative terms, the 10% fat group showed the least variation and was closest to normal group. (4) Conclusion: Lower fat intake is beneficial to maintaining metabolic stability and lessening organ damage after burns, but percentage of fat supply should not be less than 10% in burned rats.https://www.mdpi.com/2072-6643/14/17/3653burnscarbohydrate–fat ratioenteral nutritionhypermetabolismorgan damage |
| spellingShingle | Yongjun Yang Sen Su Yong Zhang Dan Wu Chao Wang Yan Wei Xi Peng Effects of Different Ratios of Carbohydrate–Fat in Enteral Nutrition on Metabolic Pattern and Organ Damage in Burned Rats Nutrients burns carbohydrate–fat ratio enteral nutrition hypermetabolism organ damage |
| title | Effects of Different Ratios of Carbohydrate–Fat in Enteral Nutrition on Metabolic Pattern and Organ Damage in Burned Rats |
| title_full | Effects of Different Ratios of Carbohydrate–Fat in Enteral Nutrition on Metabolic Pattern and Organ Damage in Burned Rats |
| title_fullStr | Effects of Different Ratios of Carbohydrate–Fat in Enteral Nutrition on Metabolic Pattern and Organ Damage in Burned Rats |
| title_full_unstemmed | Effects of Different Ratios of Carbohydrate–Fat in Enteral Nutrition on Metabolic Pattern and Organ Damage in Burned Rats |
| title_short | Effects of Different Ratios of Carbohydrate–Fat in Enteral Nutrition on Metabolic Pattern and Organ Damage in Burned Rats |
| title_sort | effects of different ratios of carbohydrate fat in enteral nutrition on metabolic pattern and organ damage in burned rats |
| topic | burns carbohydrate–fat ratio enteral nutrition hypermetabolism organ damage |
| url | https://www.mdpi.com/2072-6643/14/17/3653 |
| work_keys_str_mv | AT yongjunyang effectsofdifferentratiosofcarbohydratefatinenteralnutritiononmetabolicpatternandorgandamageinburnedrats AT sensu effectsofdifferentratiosofcarbohydratefatinenteralnutritiononmetabolicpatternandorgandamageinburnedrats AT yongzhang effectsofdifferentratiosofcarbohydratefatinenteralnutritiononmetabolicpatternandorgandamageinburnedrats AT danwu effectsofdifferentratiosofcarbohydratefatinenteralnutritiononmetabolicpatternandorgandamageinburnedrats AT chaowang effectsofdifferentratiosofcarbohydratefatinenteralnutritiononmetabolicpatternandorgandamageinburnedrats AT yanwei effectsofdifferentratiosofcarbohydratefatinenteralnutritiononmetabolicpatternandorgandamageinburnedrats AT xipeng effectsofdifferentratiosofcarbohydratefatinenteralnutritiononmetabolicpatternandorgandamageinburnedrats |