Seasonality in the incidence of anti‐GQ1b antibody syndrome—A territory‐wide study
Abstract Aims To investigate any seasonality in the incidence of anti‐GQ1b antibody syndrome (AGS). Methods We conducted a retrospective observational study in all hospitalized patients in local public hospitals from January 2013 to December 2018. AGS was defined by hospitalized patients with positi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-10-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2337 |
| _version_ | 1818730953292382208 |
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| author | Richard Shek‐kwan Chang Eric H. Y. Lau Elaine Yuen Ling Au William C. Y. Leung Yu Hin Ian Leung |
| author_facet | Richard Shek‐kwan Chang Eric H. Y. Lau Elaine Yuen Ling Au William C. Y. Leung Yu Hin Ian Leung |
| author_sort | Richard Shek‐kwan Chang |
| collection | DOAJ |
| description | Abstract Aims To investigate any seasonality in the incidence of anti‐GQ1b antibody syndrome (AGS). Methods We conducted a retrospective observational study in all hospitalized patients in local public hospitals from January 2013 to December 2018. AGS was defined by hospitalized patients with positive serum anti‐GQ1b IgG, presumably encompassing Miller‐Fisher syndrome, Bickerstaff brainstem encephalitis and Guillain–Barré syndrome (GBS) variants. GBS cases were retrieved from the computerized database by diagnostic label. Campylobacter jejuni infection (CJI) injection was identified by positive stool culture. Monthly incidence rates of AGS, GBS and CJI were calculated. Poisson and negative binomial regression models with long‐term time trend were fitted to characterize the seasonal pattern. Results A total of 237, 572 and 2434 cases of AGS, GBS and CJI were identified, respectively, in a population of 7.3 million. The annual incidence rate of AGS was 0.54 per 100,000 person‐years. AGS was demonstrated to have an annual peak in the spring season, from March to April, which was congruent with that of GBS and slightly lagged the annual peak of CJI from February to March (likelihood ratio tests all p < .001 for the seasonal terms). Conclusion The incidence of AGS peaks in springtime, which is congruent with that of GBS and lags around one month after that of CJI. We demonstrated that AGS has a clear seasonality in occurrence. |
| first_indexed | 2024-12-17T23:09:58Z |
| format | Article |
| id | doaj.art-1f0e51d2dd964dfb95c60b09cd16a863 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-17T23:09:58Z |
| publishDate | 2021-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-1f0e51d2dd964dfb95c60b09cd16a8632022-12-21T21:29:09ZengWileyBrain and Behavior2162-32792021-10-011110n/an/a10.1002/brb3.2337Seasonality in the incidence of anti‐GQ1b antibody syndrome—A territory‐wide studyRichard Shek‐kwan Chang0Eric H. Y. Lau1Elaine Yuen Ling Au2William C. Y. Leung3Yu Hin Ian Leung4Division of Neurology, Department of Medicine, Queen Mary Hospital University of Hong Kong Hong Kong SAR ChinaSchool of Public Health, Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong SAR ChinaDivision of Clinical Immunology, Department of Pathology, Queen Mary Hospital University of Hong Kong Hong Kong SAR ChinaDivision of Neurology, Department of Medicine, Queen Mary Hospital University of Hong Kong Hong Kong SAR ChinaDivision of Neurology, Department of Medicine, Queen Mary Hospital University of Hong Kong Hong Kong SAR ChinaAbstract Aims To investigate any seasonality in the incidence of anti‐GQ1b antibody syndrome (AGS). Methods We conducted a retrospective observational study in all hospitalized patients in local public hospitals from January 2013 to December 2018. AGS was defined by hospitalized patients with positive serum anti‐GQ1b IgG, presumably encompassing Miller‐Fisher syndrome, Bickerstaff brainstem encephalitis and Guillain–Barré syndrome (GBS) variants. GBS cases were retrieved from the computerized database by diagnostic label. Campylobacter jejuni infection (CJI) injection was identified by positive stool culture. Monthly incidence rates of AGS, GBS and CJI were calculated. Poisson and negative binomial regression models with long‐term time trend were fitted to characterize the seasonal pattern. Results A total of 237, 572 and 2434 cases of AGS, GBS and CJI were identified, respectively, in a population of 7.3 million. The annual incidence rate of AGS was 0.54 per 100,000 person‐years. AGS was demonstrated to have an annual peak in the spring season, from March to April, which was congruent with that of GBS and slightly lagged the annual peak of CJI from February to March (likelihood ratio tests all p < .001 for the seasonal terms). Conclusion The incidence of AGS peaks in springtime, which is congruent with that of GBS and lags around one month after that of CJI. We demonstrated that AGS has a clear seasonality in occurrence.https://doi.org/10.1002/brb3.2337anti‐GQ1b antibody syndromeepidemiologyGuillain–Barré syndromeneuropathy |
| spellingShingle | Richard Shek‐kwan Chang Eric H. Y. Lau Elaine Yuen Ling Au William C. Y. Leung Yu Hin Ian Leung Seasonality in the incidence of anti‐GQ1b antibody syndrome—A territory‐wide study Brain and Behavior anti‐GQ1b antibody syndrome epidemiology Guillain–Barré syndrome neuropathy |
| title | Seasonality in the incidence of anti‐GQ1b antibody syndrome—A territory‐wide study |
| title_full | Seasonality in the incidence of anti‐GQ1b antibody syndrome—A territory‐wide study |
| title_fullStr | Seasonality in the incidence of anti‐GQ1b antibody syndrome—A territory‐wide study |
| title_full_unstemmed | Seasonality in the incidence of anti‐GQ1b antibody syndrome—A territory‐wide study |
| title_short | Seasonality in the incidence of anti‐GQ1b antibody syndrome—A territory‐wide study |
| title_sort | seasonality in the incidence of anti gq1b antibody syndrome a territory wide study |
| topic | anti‐GQ1b antibody syndrome epidemiology Guillain–Barré syndrome neuropathy |
| url | https://doi.org/10.1002/brb3.2337 |
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