Correlation between the Inflammation Factors and Intima-Media Thickness in Patients with End-Stage Renal Disease (ESRD) on Regular Hemodialysis
Background: Several emerging problems of regular hemodialysis (HD) including cardiovascular complication or atherosclerosis formation caused by chronic inflammation. High sensitive C-reactive protein (hs-CRP) and intima-media thickness (IMT) of the carotid artery can be applied as atherosclerosis pr...
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| Format: | Article |
| Language: | English |
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Cell and BioPharmaceutical Institute
2019-03-01
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| Series: | MCBS (Molecular and Cellular Biomedical Sciences) |
| Online Access: | https://www.cellbiopharm.com/ojs/index.php/MCBS/article/view/51 |
| _version_ | 1818422726690340864 |
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| author | Lestariningsih Lestaringsih Wiguno Projosudjadi Mochamad Sya’bani Suharyo Hadisaputro |
| author_facet | Lestariningsih Lestaringsih Wiguno Projosudjadi Mochamad Sya’bani Suharyo Hadisaputro |
| author_sort | Lestariningsih Lestaringsih |
| collection | DOAJ |
| description | Background: Several emerging problems of regular hemodialysis (HD) including cardiovascular complication or atherosclerosis formation caused by chronic inflammation. High sensitive C-reactive protein (hs-CRP) and intima-media thickness (IMT) of the carotid artery can be applied as atherosclerosis progressivity marker. This study was designed to investigate the relationship between some inflammatory factors, including hs-CRP, interleukin (IL)-6, oxidized-low-density lipoproteins (LDL), with IMT among end-stage renal disease (ESRD) patients. This was the first study in Indonesian population.
Materials and Methods: This cross-sectional study was performed on ESRD patients who performed regular HD at Hemodialysis Unit of Dr. Kariadi Hospital and Telogorejo Hospital Semarang between October 2009 and April 2010. This was a preliminary report for the cohort study.
Results: Seventy-eight HD subjects were enrolled in this study, with mean age of 49.8 years old. Mean HD duration was 25.5±32.16 months. The mean carotid artery wall thickness was 0.64±0.149 mm. IL-6, hs-CRP, and ox-LDL level were higher in IMT group ≥0.5 mm than IMT group <0.5 mm. There was a significant correlation between hs-CRP (prevalence ratio (PR)=1.3; 95% confidence interval (CI)=1.02-1.7; p-value=0.01) as well as IL-6 (PR=1.5; 95% CI=1.1 -2.0; p-value<0.001) and IMT wall thickness. The oxidized-LDL level was not a significant factor to be associated with IMT. The cut-off value for hs-CRP and IL-6 to predict IMT progressivity was 2.8 mg/L and 2.88 mg/L, respectively.
Conclusion: There was a significant correlation between IL-6 and hs-CRP levels and IMT. There was not significant correlation between oxidized LDL and IMT.
Keywords: hemodialysis, atherosclerosis, IMT, IL-6, hs-CRP, Oxidized-LDL |
| first_indexed | 2024-12-14T13:30:50Z |
| format | Article |
| id | doaj.art-1f0f18c0f7d1439abc61ab844d5e06cc |
| institution | Directory Open Access Journal |
| issn | 2527-4384 2527-3442 |
| language | English |
| last_indexed | 2024-12-14T13:30:50Z |
| publishDate | 2019-03-01 |
| publisher | Cell and BioPharmaceutical Institute |
| record_format | Article |
| series | MCBS (Molecular and Cellular Biomedical Sciences) |
| spelling | doaj.art-1f0f18c0f7d1439abc61ab844d5e06cc2022-12-21T22:59:42ZengCell and BioPharmaceutical InstituteMCBS (Molecular and Cellular Biomedical Sciences)2527-43842527-34422019-03-0131485310.21705/mcbs.v3i1.5129Correlation between the Inflammation Factors and Intima-Media Thickness in Patients with End-Stage Renal Disease (ESRD) on Regular HemodialysisLestariningsih Lestaringsih0Wiguno Projosudjadi1Mochamad Sya’bani2Suharyo Hadisaputro3Division of Nephrology, Department of Internal Medicine, School of Medicine, Universitas Diponegoro/ Dr. Kariadi Teaching Hospital, SemarangDivision of Nephrology, Department of Internal Medicine, Universitas Indonesia, JakartaDivision of Nephrology, Department of Internal Medicine, Universitas Gadjah Mada, YogjakartaDivision of Tropic Infection, Department of Internal Medicine, Universitas Diponegoro, SemarangBackground: Several emerging problems of regular hemodialysis (HD) including cardiovascular complication or atherosclerosis formation caused by chronic inflammation. High sensitive C-reactive protein (hs-CRP) and intima-media thickness (IMT) of the carotid artery can be applied as atherosclerosis progressivity marker. This study was designed to investigate the relationship between some inflammatory factors, including hs-CRP, interleukin (IL)-6, oxidized-low-density lipoproteins (LDL), with IMT among end-stage renal disease (ESRD) patients. This was the first study in Indonesian population. Materials and Methods: This cross-sectional study was performed on ESRD patients who performed regular HD at Hemodialysis Unit of Dr. Kariadi Hospital and Telogorejo Hospital Semarang between October 2009 and April 2010. This was a preliminary report for the cohort study. Results: Seventy-eight HD subjects were enrolled in this study, with mean age of 49.8 years old. Mean HD duration was 25.5±32.16 months. The mean carotid artery wall thickness was 0.64±0.149 mm. IL-6, hs-CRP, and ox-LDL level were higher in IMT group ≥0.5 mm than IMT group <0.5 mm. There was a significant correlation between hs-CRP (prevalence ratio (PR)=1.3; 95% confidence interval (CI)=1.02-1.7; p-value=0.01) as well as IL-6 (PR=1.5; 95% CI=1.1 -2.0; p-value<0.001) and IMT wall thickness. The oxidized-LDL level was not a significant factor to be associated with IMT. The cut-off value for hs-CRP and IL-6 to predict IMT progressivity was 2.8 mg/L and 2.88 mg/L, respectively. Conclusion: There was a significant correlation between IL-6 and hs-CRP levels and IMT. There was not significant correlation between oxidized LDL and IMT. Keywords: hemodialysis, atherosclerosis, IMT, IL-6, hs-CRP, Oxidized-LDLhttps://www.cellbiopharm.com/ojs/index.php/MCBS/article/view/51 |
| spellingShingle | Lestariningsih Lestaringsih Wiguno Projosudjadi Mochamad Sya’bani Suharyo Hadisaputro Correlation between the Inflammation Factors and Intima-Media Thickness in Patients with End-Stage Renal Disease (ESRD) on Regular Hemodialysis MCBS (Molecular and Cellular Biomedical Sciences) |
| title | Correlation between the Inflammation Factors and Intima-Media Thickness in Patients with End-Stage Renal Disease (ESRD) on Regular Hemodialysis |
| title_full | Correlation between the Inflammation Factors and Intima-Media Thickness in Patients with End-Stage Renal Disease (ESRD) on Regular Hemodialysis |
| title_fullStr | Correlation between the Inflammation Factors and Intima-Media Thickness in Patients with End-Stage Renal Disease (ESRD) on Regular Hemodialysis |
| title_full_unstemmed | Correlation between the Inflammation Factors and Intima-Media Thickness in Patients with End-Stage Renal Disease (ESRD) on Regular Hemodialysis |
| title_short | Correlation between the Inflammation Factors and Intima-Media Thickness in Patients with End-Stage Renal Disease (ESRD) on Regular Hemodialysis |
| title_sort | correlation between the inflammation factors and intima media thickness in patients with end stage renal disease esrd on regular hemodialysis |
| url | https://www.cellbiopharm.com/ojs/index.php/MCBS/article/view/51 |
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