Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity

Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity

ABSTRACTToxoplasma gondii is an intracellular parasite that can activate the NLRP1 inflammasome leading to macrophage pyroptosis in Lewis rats, but the underlying mechanism is not well understood. In this study, we performed a genome-wide CRISPR screen and identified the dense granule proteins GRA35...

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Bibliographic Details
Main Authors: Yifan Wang, L. Robert Hollingsworth, Lamba Omar Sangaré, Tatiana C. Paredes-Santos, Shruthi Krishnamurthy, Bennett H. Penn, Hao Wu, Jeroen P. J. Saeij
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mBio
Subjects:
E3 ubiquitin ligase
effector-triggered immunity
NLRP1 inflammasome
IFNγ
Toxoplasma gondii
Online Access:https://journals.asm.org/doi/10.1128/mbio.03302-23

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