Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection
Increasing pest and pathogen challenges as well as having fewer conventional pesticides to employ require innovative and sustainable solutions for plant protection. One group of pesticides that is in the pipeline and is expected to be subject to regulation and risk assessment procedures in the near...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2021.682387/full |
| _version_ | 1818587441503666176 |
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| author | Antje Dietz-Pfeilstetter Mike Mendelsohn Achim Gathmann Dominik Klinkenbuß |
| author_facet | Antje Dietz-Pfeilstetter Mike Mendelsohn Achim Gathmann Dominik Klinkenbuß |
| author_sort | Antje Dietz-Pfeilstetter |
| collection | DOAJ |
| description | Increasing pest and pathogen challenges as well as having fewer conventional pesticides to employ require innovative and sustainable solutions for plant protection. One group of pesticides that is in the pipeline and is expected to be subject to regulation and risk assessment procedures in the near future, is based on the natural gene silencing mechanism RNA interference (RNAi). These dsRNA-based products can be highly specific for a target organism due to the sequence-specific interaction between effective small interfering RNAs (siRNAs) and a complementary target RNA. General regulatory frameworks for pesticide authorization in the U.S. and in the EU are presented. In addition, production and application procedures and specific characteristics of dsRNA-based pesticides relevant for risk assessment and regulation are considered. |
| first_indexed | 2024-12-16T09:08:55Z |
| format | Article |
| id | doaj.art-1f132c47838140fd9f635a2abc3221b7 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-16T09:08:55Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-1f132c47838140fd9f635a2abc3221b72022-12-21T22:37:01ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2021-06-011210.3389/fpls.2021.682387682387Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant ProtectionAntje Dietz-Pfeilstetter0Mike Mendelsohn1Achim Gathmann2Dominik Klinkenbuß3Federal Research Centre for Cultivated Plants, Institute for Biosafety in Plant Biotechnology, Julius Kühn-Institut, Braunschweig, GermanyBiopesticides and Pollution Prevention Division, Office of Pesticide Programs, United States Environmental Protection Agency, Washington, DC, United StatesFederal Office of Consumer Protection and Food Safety, Department of Plant Protection Products, Unit Environment, Braunschweig, GermanyFederal Office of Consumer Protection and Food Safety, Department of Plant Protection Products, Unit Environment, Braunschweig, GermanyIncreasing pest and pathogen challenges as well as having fewer conventional pesticides to employ require innovative and sustainable solutions for plant protection. One group of pesticides that is in the pipeline and is expected to be subject to regulation and risk assessment procedures in the near future, is based on the natural gene silencing mechanism RNA interference (RNAi). These dsRNA-based products can be highly specific for a target organism due to the sequence-specific interaction between effective small interfering RNAs (siRNAs) and a complementary target RNA. General regulatory frameworks for pesticide authorization in the U.S. and in the EU are presented. In addition, production and application procedures and specific characteristics of dsRNA-based pesticides relevant for risk assessment and regulation are considered.https://www.frontiersin.org/articles/10.3389/fpls.2021.682387/fullplant protectionpesticidedsRNASIGSpesticide regulation |
| spellingShingle | Antje Dietz-Pfeilstetter Mike Mendelsohn Achim Gathmann Dominik Klinkenbuß Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection Frontiers in Plant Science plant protection pesticide dsRNA SIGS pesticide regulation |
| title | Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection |
| title_full | Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection |
| title_fullStr | Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection |
| title_full_unstemmed | Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection |
| title_short | Considerations and Regulatory Approaches in the USA and in the EU for dsRNA-Based Externally Applied Pesticides for Plant Protection |
| title_sort | considerations and regulatory approaches in the usa and in the eu for dsrna based externally applied pesticides for plant protection |
| topic | plant protection pesticide dsRNA SIGS pesticide regulation |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2021.682387/full |
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