Chlorogenic Acid Restores Ovarian Functions in Mice with Letrozole-Induced Polycystic Ovarian Syndrome Via Modulation of Adiponectin Receptor
Around the world, polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic condition that typically affects 6–20% of females. Our study’s major goal was to examine how chlorogenic acid (CGA) affected mice with endocrine and metabolic problems brought on by letrozole-induced PCOS. Group I se...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/3/900 |
| _version_ | 1797613251788275712 |
|---|---|
| author | Mohd Zahoor ul Haq Shah Vinoy Kumar Shrivastava Shazia Sofi Yahya F. Jamous Mohd Faiyaz Khan Faisal K. Alkholifi Wasim Ahmad Manzoor Ahmad Mir |
| author_facet | Mohd Zahoor ul Haq Shah Vinoy Kumar Shrivastava Shazia Sofi Yahya F. Jamous Mohd Faiyaz Khan Faisal K. Alkholifi Wasim Ahmad Manzoor Ahmad Mir |
| author_sort | Mohd Zahoor ul Haq Shah |
| collection | DOAJ |
| description | Around the world, polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic condition that typically affects 6–20% of females. Our study’s major goal was to examine how chlorogenic acid (CGA) affected mice with endocrine and metabolic problems brought on by letrozole-induced PCOS. Group I served as the control for 81 days; Group II was given Letrozole (LETZ) orally at a dose of 6 mg/kg bw for 21 days to induce PCOS; Group III was given LETZ (6 mg/kg) for 21 days, followed by treatment with CGA (50 mg/kg bw daily) for 60 days. The study indicated that LETZ-treated mice displayed symptoms of PCOS, such as dyslipidemia, hyperinsulinemia, elevated testosterone, increases in inflammatory markers and malonaldehyde, and a decline in antioxidants (Ar, lhr, fshr, and esr2) in the ovaries. These alterations were affected when the mice were given CGA and were associated with reduced levels of adiponectin. Adiponectin showed interactions with hub genes, namely MLX interacting protein like (MLXIPL), peroxisome proliferator-activated receptor gamma Coactivator 1- alpha (PPARGC1), peroxisome proliferator-activated receptor gamma (Pparg), and adiponectin receptor 1 (Adipor1). Lastly, the gene ontology of adiponectin revealed that adiponectin was highly involved in biological processes. The findings from our research suggest that adiponectin has direct impacts on metabolic and endocrine facets of PCOS. |
| first_indexed | 2024-03-11T06:53:14Z |
| format | Article |
| id | doaj.art-1f135f4a107f4741a7c684bc1cdb6327 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:14Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1f135f4a107f4741a7c684bc1cdb63272023-11-17T09:47:16ZengMDPI AGBiomedicines2227-90592023-03-0111390010.3390/biomedicines11030900Chlorogenic Acid Restores Ovarian Functions in Mice with Letrozole-Induced Polycystic Ovarian Syndrome Via Modulation of Adiponectin ReceptorMohd Zahoor ul Haq Shah0Vinoy Kumar Shrivastava1Shazia Sofi2Yahya F. Jamous3Mohd Faiyaz Khan4Faisal K. Alkholifi5Wasim Ahmad6Manzoor Ahmad Mir7Endocrinology Unit, Department of Bioscience, Barkatullah University, Bhopal 462026, IndiaEndocrinology Unit, Department of Bioscience, Barkatullah University, Bhopal 462026, IndiaDepartment of Bioresources, School of Biological Sciences, University of Kashmir Srinagar, Srinagar 190006, IndiaVaccine and Bioprocessing Centre, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj 16278, Saudi ArabiaDepartment of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj 16278, Saudi ArabiaDepartment of Pharmacy, Mohammad Al-Mana College for Medical Sciences, Damman 34222, Saudi ArabiaDepartment of Bioresources, School of Biological Sciences, University of Kashmir Srinagar, Srinagar 190006, IndiaAround the world, polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic condition that typically affects 6–20% of females. Our study’s major goal was to examine how chlorogenic acid (CGA) affected mice with endocrine and metabolic problems brought on by letrozole-induced PCOS. Group I served as the control for 81 days; Group II was given Letrozole (LETZ) orally at a dose of 6 mg/kg bw for 21 days to induce PCOS; Group III was given LETZ (6 mg/kg) for 21 days, followed by treatment with CGA (50 mg/kg bw daily) for 60 days. The study indicated that LETZ-treated mice displayed symptoms of PCOS, such as dyslipidemia, hyperinsulinemia, elevated testosterone, increases in inflammatory markers and malonaldehyde, and a decline in antioxidants (Ar, lhr, fshr, and esr2) in the ovaries. These alterations were affected when the mice were given CGA and were associated with reduced levels of adiponectin. Adiponectin showed interactions with hub genes, namely MLX interacting protein like (MLXIPL), peroxisome proliferator-activated receptor gamma Coactivator 1- alpha (PPARGC1), peroxisome proliferator-activated receptor gamma (Pparg), and adiponectin receptor 1 (Adipor1). Lastly, the gene ontology of adiponectin revealed that adiponectin was highly involved in biological processes. The findings from our research suggest that adiponectin has direct impacts on metabolic and endocrine facets of PCOS.https://www.mdpi.com/2227-9059/11/3/900chlorogenic acidPCOSadiponectinletrozoleoxidative stressinflammation |
| spellingShingle | Mohd Zahoor ul Haq Shah Vinoy Kumar Shrivastava Shazia Sofi Yahya F. Jamous Mohd Faiyaz Khan Faisal K. Alkholifi Wasim Ahmad Manzoor Ahmad Mir Chlorogenic Acid Restores Ovarian Functions in Mice with Letrozole-Induced Polycystic Ovarian Syndrome Via Modulation of Adiponectin Receptor Biomedicines chlorogenic acid PCOS adiponectin letrozole oxidative stress inflammation |
| title | Chlorogenic Acid Restores Ovarian Functions in Mice with Letrozole-Induced Polycystic Ovarian Syndrome Via Modulation of Adiponectin Receptor |
| title_full | Chlorogenic Acid Restores Ovarian Functions in Mice with Letrozole-Induced Polycystic Ovarian Syndrome Via Modulation of Adiponectin Receptor |
| title_fullStr | Chlorogenic Acid Restores Ovarian Functions in Mice with Letrozole-Induced Polycystic Ovarian Syndrome Via Modulation of Adiponectin Receptor |
| title_full_unstemmed | Chlorogenic Acid Restores Ovarian Functions in Mice with Letrozole-Induced Polycystic Ovarian Syndrome Via Modulation of Adiponectin Receptor |
| title_short | Chlorogenic Acid Restores Ovarian Functions in Mice with Letrozole-Induced Polycystic Ovarian Syndrome Via Modulation of Adiponectin Receptor |
| title_sort | chlorogenic acid restores ovarian functions in mice with letrozole induced polycystic ovarian syndrome via modulation of adiponectin receptor |
| topic | chlorogenic acid PCOS adiponectin letrozole oxidative stress inflammation |
| url | https://www.mdpi.com/2227-9059/11/3/900 |
| work_keys_str_mv | AT mohdzahoorulhaqshah chlorogenicacidrestoresovarianfunctionsinmicewithletrozoleinducedpolycysticovariansyndromeviamodulationofadiponectinreceptor AT vinoykumarshrivastava chlorogenicacidrestoresovarianfunctionsinmicewithletrozoleinducedpolycysticovariansyndromeviamodulationofadiponectinreceptor AT shaziasofi chlorogenicacidrestoresovarianfunctionsinmicewithletrozoleinducedpolycysticovariansyndromeviamodulationofadiponectinreceptor AT yahyafjamous chlorogenicacidrestoresovarianfunctionsinmicewithletrozoleinducedpolycysticovariansyndromeviamodulationofadiponectinreceptor AT mohdfaiyazkhan chlorogenicacidrestoresovarianfunctionsinmicewithletrozoleinducedpolycysticovariansyndromeviamodulationofadiponectinreceptor AT faisalkalkholifi chlorogenicacidrestoresovarianfunctionsinmicewithletrozoleinducedpolycysticovariansyndromeviamodulationofadiponectinreceptor AT wasimahmad chlorogenicacidrestoresovarianfunctionsinmicewithletrozoleinducedpolycysticovariansyndromeviamodulationofadiponectinreceptor AT manzoorahmadmir chlorogenicacidrestoresovarianfunctionsinmicewithletrozoleinducedpolycysticovariansyndromeviamodulationofadiponectinreceptor |