Ablation of the Chaperone Protein ERdj5 Results in a Sjögren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients

Ablation of the Chaperone Protein ERdj5 Results in a Sjögren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients

Objective: Sjögren's syndrome (SS) is a chronic autoimmune disorder that affects mainly the exocrine glands. Endoplasmic reticulum (ER) stress proteins have been suggested to participate in autoimmune and inflammatory responses, either acting as autoantigens, or by modulating factors of inflamm...

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Bibliographic Details
Main Authors: Eirini Apostolou, Petros Moustardas, Takao Iwawaki, Athanasios G. Tzioufas, Giannis Spyrou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
ERdj5
ER-stress
autoimmunity
salivary gland
Sjögren's syndrome
XBP1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00506/full

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