Mutations and modeling of the chromatin remodeler CHD8 define an emerging autism etiology

Mutations and modeling of the chromatin remodeler CHD8 define an emerging autism etiology

Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder with a strong but complex genetic component. Recent family based exome-sequencing strategies have identified recurrent de novo mutations at specific genes, providing strong evidence for ASD risk, but also highlighting the extreme...

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Bibliographic Details
Main Authors: Rebecca A Barnard, Matthew B Pomaville, Brian J O'Roak
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Neuroscience
Subjects:
Systems Biology
autism
Functional Genomics
Autism spectrum disorder (ASD)
co-expression networks
De novo mutations
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00477/full

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