Genetic distinction between functional tissue-resident and conventional natural killer cells
Summary: Tissue-residential natural killer (trNK) cells act as pioneering responders during infectious challenges. However, their discrimination with conventional NK (cNK) cells is still an issue. Through an integrative transcriptome comparison of the two NK subgroups from different tissues, we have...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223012646 |
| _version_ | 1797774531070263296 |
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| author | Luni Hu Mengwei Han Yichen Deng Jingjing Gong Zhiyuan Hou Yanyu Zeng Yime Zhang Jing He Chao Zhong |
| author_facet | Luni Hu Mengwei Han Yichen Deng Jingjing Gong Zhiyuan Hou Yanyu Zeng Yime Zhang Jing He Chao Zhong |
| author_sort | Luni Hu |
| collection | DOAJ |
| description | Summary: Tissue-residential natural killer (trNK) cells act as pioneering responders during infectious challenges. However, their discrimination with conventional NK (cNK) cells is still an issue. Through an integrative transcriptome comparison of the two NK subgroups from different tissues, we have defined two genesets capable of efficiently distinguishing them. Based on the two genesets, a fundamental difference between the activation of trNK and cNK is identified and further confirmed. Mechanistically, we have discovered a particular role of chromatin landscape in regulating the trNK activation. In addition, IL-21R and IL-18R are respectively highly expressed by trNK and cNK, indicating a role of cytokine milieu in determining their differential activation. Indeed, IL-21 is particularly critical in accessorily promoting trNK activation using a bunch of bifunctional transcription factors. Together, this study sheds light on the bona fide difference between trNK and cNK, which will further expand our knowledge about their distinct functionalities during immune responses. |
| first_indexed | 2024-03-12T22:21:27Z |
| format | Article |
| id | doaj.art-1f150adad3d44e86a32b568e966a4f7c |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T22:21:27Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-1f150adad3d44e86a32b568e966a4f7c2023-07-23T04:55:52ZengElsevieriScience2589-00422023-07-01267107187Genetic distinction between functional tissue-resident and conventional natural killer cellsLuni Hu0Mengwei Han1Yichen Deng2Jingjing Gong3Zhiyuan Hou4Yanyu Zeng5Yime Zhang6Jing He7Chao Zhong8Institute of Systems Biomedicine, Department of Immunology, NHC Key Laboratory of Medical Immunology (Peking University), Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaInstitute of Systems Biomedicine, Department of Immunology, NHC Key Laboratory of Medical Immunology (Peking University), Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaInstitute of Systems Biomedicine, Department of Immunology, NHC Key Laboratory of Medical Immunology (Peking University), Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaInstitute of Systems Biomedicine, Peking University Health Science Center, Beijing 100191, ChinaInstitute of Systems Biomedicine, Peking University Health Science Center, Beijing 100191, ChinaInstitute of Systems Biomedicine, Department of Immunology, NHC Key Laboratory of Medical Immunology (Peking University), Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaInstitute of Systems Biomedicine, Department of Immunology, NHC Key Laboratory of Medical Immunology (Peking University), Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Rheumatology and Immunology, Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis, Peking University People’s Hospital, Beijing, ChinaInstitute of Systems Biomedicine, Department of Immunology, NHC Key Laboratory of Medical Immunology (Peking University), Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Corresponding authorSummary: Tissue-residential natural killer (trNK) cells act as pioneering responders during infectious challenges. However, their discrimination with conventional NK (cNK) cells is still an issue. Through an integrative transcriptome comparison of the two NK subgroups from different tissues, we have defined two genesets capable of efficiently distinguishing them. Based on the two genesets, a fundamental difference between the activation of trNK and cNK is identified and further confirmed. Mechanistically, we have discovered a particular role of chromatin landscape in regulating the trNK activation. In addition, IL-21R and IL-18R are respectively highly expressed by trNK and cNK, indicating a role of cytokine milieu in determining their differential activation. Indeed, IL-21 is particularly critical in accessorily promoting trNK activation using a bunch of bifunctional transcription factors. Together, this study sheds light on the bona fide difference between trNK and cNK, which will further expand our knowledge about their distinct functionalities during immune responses.http://www.sciencedirect.com/science/article/pii/S2589004223012646Biological sciencesMolecular biologyEpigeneticsImmunology |
| spellingShingle | Luni Hu Mengwei Han Yichen Deng Jingjing Gong Zhiyuan Hou Yanyu Zeng Yime Zhang Jing He Chao Zhong Genetic distinction between functional tissue-resident and conventional natural killer cells iScience Biological sciences Molecular biology Epigenetics Immunology |
| title | Genetic distinction between functional tissue-resident and conventional natural killer cells |
| title_full | Genetic distinction between functional tissue-resident and conventional natural killer cells |
| title_fullStr | Genetic distinction between functional tissue-resident and conventional natural killer cells |
| title_full_unstemmed | Genetic distinction between functional tissue-resident and conventional natural killer cells |
| title_short | Genetic distinction between functional tissue-resident and conventional natural killer cells |
| title_sort | genetic distinction between functional tissue resident and conventional natural killer cells |
| topic | Biological sciences Molecular biology Epigenetics Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223012646 |
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