Generation and Characterization of the <i>Drosophila melanogaster paralytic</i> Gene Knock-Out as a Model for Dravet Syndrome

Generation and Characterization of the <i>Drosophila melanogaster paralytic</i> Gene Knock-Out as a Model for Dravet Syndrome

Dravet syndrome is a severe rare epileptic disease caused by mutations in the <i>SCN1A</i> gene coding for the Nav1.1 protein, a voltage-gated sodium channel alpha subunit. We have made a knock-out of the <i>paralytic</i> gene, the single <i>Drosophila melanogaster</...

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Bibliographic Details
Main Authors: Andrea Tapia, Carlo N. Giachello, Martina Palomino-Schätzlein, Richard A. Baines, Máximo Ibo Galindo
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Life
Subjects:
Dravet syndrome
epilepsy
voltage-gated sodium channel
gabaergic neurons
electrophysiology
metabolomics
Online Access:https://www.mdpi.com/2075-1729/11/11/1261

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