Histomorphological Analysis of Upper Gastrointestinal Endoscopic Biopsies: A Retrospective Study of 106 Cases
Introduction: A variety of disorders affect the upper gastrointestinal tract. Study of endoscopic biopsies is imperative to make an accurate diagnosis, which will aid in early diagnosis and appropriate management of the patient. Aim: To determine the histomorphological spectrum and the occurren...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2019-10-01
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| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/2363/42216_PD(V-1_KM)_CE[Ra1]_F(SHU)_PF1(AG_SHU)_PFA(SHU)_PB(PoG_SHU)_PN(SHU).pdf |
| Summary: | Introduction: A variety of disorders affect the upper
gastrointestinal tract. Study of endoscopic biopsies is imperative
to make an accurate diagnosis, which will aid in early diagnosis
and appropriate management of the patient.
Aim: To determine the histomorphological spectrum and
the occurrence of upper gastrointestinal lesions; and also to
associate endoscopic diagnosis with histopathology.
Materials and Methods: This was a retrospective, descriptive
study conducted from May 2017 to April 2019 on 106 cases,
done at BGS Global Institute of Medical Sciences, Bengaluru,
Karnataka, India. Microscopic findings were studied by two
pathologists.
Results: A total of 106 cases were studied. Majority of the
patients (56%) presented with abdominal pain followed by
dyspepsia and dysphagia. Stomach was the most common site
of biopsy followed by oesophagus and duodenum. Majority of
oesophageal and gastric biopsies were found to be neoplastic
i.e., 70.8% and 56.3% respectively; however, non-neoplastic
lesions formed the majority in duodenal biopsies (88.9%). The
most common malignancy was squamous cell carcinoma,
which occurred predominantly in the middle third of the
oesophagus. The most common malignancy in the stomach
was adenocarcinoma. Correlation between endoscopic
diagnosis and histopathology was done in 70 cases; and there
was consensus in 78.5% of the cases (55/70 cases).
Conclusion: Endoscopy with assisted biopsy is the gold
standard for diagnosis of upper gastrointestinal disorders. An
interdisciplinary approach towards diagnosis and treatment
involving the pathologist and clinician is important. |
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| ISSN: | 2277-8551 2455-6882 |