Role of Histone Tails and Single Strand DNA Breaks in Nucleosomal Arrest of RNA Polymerase

Role of Histone Tails and Single Strand DNA Breaks in Nucleosomal Arrest of RNA Polymerase

Transcription through nucleosomes by RNA polymerases (RNAP) is accompanied by formation of small intranucleosomal DNA loops (i-loops). The i-loops form more efficiently in the presence of single-strand breaks or gaps in a non-template DNA strand (NT-SSBs) and induce arrest of transcribing RNAP, thus...

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Bibliographic Details
Main Authors: Nadezhda S. Gerasimova, Nikolay A. Pestov, Vasily M. Studitsky
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
DNA damage
DNA loop
chromatin structure
nucleosome
single-strand DNA breaks
transcription-coupled DNA repair
Online Access:https://www.mdpi.com/1422-0067/24/3/2295

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