HIF1α/TET1 Pathway Mediates Hypoxia-Induced Adipocytokine Promoter Hypomethylation in Human Adipocytes

HIF1α/TET1 Pathway Mediates Hypoxia-Induced Adipocytokine Promoter Hypomethylation in Human Adipocytes

Obesity is associated with the accumulation of dysfunctional adipose tissue that secretes several pro-inflammatory cytokines (adipocytokines). Recent studies have presented evidence that adipose tissues in obese individuals and animal models are hypoxic, which may result in upregulation and stabiliz...

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Bibliographic Details
Main Authors:	Mohamed M. Ali, Shane A. Phillips, Abeer M. Mahmoud
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Series:	Cells
Subjects:	adipocytes hypoxia inflammation dna methylation hif1α tet1 adipocytokines epigenetics
Online Access:	https://www.mdpi.com/2073-4409/9/1/134

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