Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study
Abstract Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics pre...
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| Format: | Article |
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Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-36235-9 |
| _version_ | 1827928611848454144 |
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| author | Tesfa Dejenie Habtewold Natalia Tiles-Sar Edith J. Liemburg Amrit Kaur Sandhu Md Atiqul Islam H. Marike Boezen GROUP Investigators Richard Bruggeman Behrooz Z. Alizadeh |
| author_facet | Tesfa Dejenie Habtewold Natalia Tiles-Sar Edith J. Liemburg Amrit Kaur Sandhu Md Atiqul Islam H. Marike Boezen GROUP Investigators Richard Bruggeman Behrooz Z. Alizadeh |
| author_sort | Tesfa Dejenie Habtewold |
| collection | DOAJ |
| description | Abstract Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors of homogenous subgroups of the long-term course of positive and negative symptoms in SSD patients (n = 1119) and their unaffected siblings (n = 1059) in comparison to controls (n = 586). Data were collected at baseline, and after 3- and 6-year follow-ups. Group-based trajectory modeling was applied to identify latent subgroups using positive and negative symptoms or schizotypy scores. A multinomial random-effects logistic regression model was used to identify predictors of latent subgroups. Patients had decreasing, increasing, and relapsing symptoms course. Unaffected siblings and healthy controls had three to four subgroups characterized by stable, decreasing, or increasing schizotypy. PRSSCZ did not predict the latent subgroups. Baseline symptoms severity in patients, premorbid adjustment, depressive symptoms, and quality of life in siblings predicted long-term trajectories while were nonsignificant in controls. In conclusion, up to four homogenous latent subgroups of symptom course can be distinguished within patients, siblings, and controls, while non-genetic factors are the main factors associated with the latent subgroups. |
| first_indexed | 2024-03-13T06:11:09Z |
| format | Article |
| id | doaj.art-1f17e409eb9f40c186a99b35568d10ed |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T06:11:09Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1f17e409eb9f40c186a99b35568d10ed2023-06-11T11:14:23ZengNature PortfolioScientific Reports2045-23222023-06-0113111110.1038/s41598-023-36235-9Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) studyTesfa Dejenie Habtewold0Natalia Tiles-Sar1Edith J. Liemburg2Amrit Kaur Sandhu3Md Atiqul Islam4H. Marike Boezen5GROUP InvestigatorsRichard Bruggeman6Behrooz Z. Alizadeh7Department of Epidemiology, University Medical Center Groningen, University of GroningenDepartment of Epidemiology, University Medical Center Groningen, University of GroningenRob Giel Research Center, University Medical Center Groningen, University Center for Psychiatry, University of GroningenDepartment of Epidemiology, University Medical Center Groningen, University of GroningenDepartment of Statistics, Jagannath UniversityDepartment of Epidemiology, University Medical Center Groningen, University of GroningenRob Giel Research Center, University Medical Center Groningen, University Center for Psychiatry, University of GroningenDepartment of Epidemiology, University Medical Center Groningen, University of GroningenAbstract Positive and negative symptoms are prominent but heterogeneous characteristics of schizophrenia spectrum disorder (SSD). Within the framework of the Genetic Risk and Outcome of Psychosis (GROUP) longitudinal cohort study, we aimed to distinguish and identify the genetic and non-genetics predictors of homogenous subgroups of the long-term course of positive and negative symptoms in SSD patients (n = 1119) and their unaffected siblings (n = 1059) in comparison to controls (n = 586). Data were collected at baseline, and after 3- and 6-year follow-ups. Group-based trajectory modeling was applied to identify latent subgroups using positive and negative symptoms or schizotypy scores. A multinomial random-effects logistic regression model was used to identify predictors of latent subgroups. Patients had decreasing, increasing, and relapsing symptoms course. Unaffected siblings and healthy controls had three to four subgroups characterized by stable, decreasing, or increasing schizotypy. PRSSCZ did not predict the latent subgroups. Baseline symptoms severity in patients, premorbid adjustment, depressive symptoms, and quality of life in siblings predicted long-term trajectories while were nonsignificant in controls. In conclusion, up to four homogenous latent subgroups of symptom course can be distinguished within patients, siblings, and controls, while non-genetic factors are the main factors associated with the latent subgroups.https://doi.org/10.1038/s41598-023-36235-9 |
| spellingShingle | Tesfa Dejenie Habtewold Natalia Tiles-Sar Edith J. Liemburg Amrit Kaur Sandhu Md Atiqul Islam H. Marike Boezen GROUP Investigators Richard Bruggeman Behrooz Z. Alizadeh Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study Scientific Reports |
| title | Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study |
| title_full | Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study |
| title_fullStr | Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study |
| title_full_unstemmed | Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study |
| title_short | Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study |
| title_sort | six year trajectories and associated factors of positive and negative symptoms in schizophrenia patients siblings and controls genetic risk and outcome of psychosis group study |
| url | https://doi.org/10.1038/s41598-023-36235-9 |
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