Plasma insulin-like growth factor-1 concentration in dogs with chronic enteropathies
Plasma concentrations of insulin-like growth factor (IGF)-1 were examined in dogs suffering from food-responsive diarrhea (group FRD) or inflammatory bowel disease (group IBD) before and after treatment and compared with IGF-1 values in healthy dogs (group C). Blood of 76 dogs was sampled (FRDbefore...
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2006-01-01
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| Series: | Veterinární Medicína |
| Subjects: | |
| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-200601-0005_plasma-insulin-like-growth-factor-1-concentration-in-dogs-with-chronic-enteropathies.php |
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| author | A.C. Spichiger K. Allenspach Y. Zbinden M.G. Doherr S. Hiss J.W. Blum S.N. Sauter |
| author_facet | A.C. Spichiger K. Allenspach Y. Zbinden M.G. Doherr S. Hiss J.W. Blum S.N. Sauter |
| author_sort | A.C. Spichiger |
| collection | DOAJ |
| description | Plasma concentrations of insulin-like growth factor (IGF)-1 were examined in dogs suffering from food-responsive diarrhea (group FRD) or inflammatory bowel disease (group IBD) before and after treatment and compared with IGF-1 values in healthy dogs (group C). Blood of 76 dogs was sampled (FRDbefore treatment, n = 23; IBD before treatment, n = 11; C, n = 42) and after treatment (FRD, n = 15; IBD, n= 8) with a hypoallergenic diet combined with (group IBD) or without prednisolone (group FRD). A clinical score (Canine IBD Activity Index = CIBDAI) was applied to judge the health status in all dogs. Plasma concentration of IGF-1, of total protein, albumin, glucose, urea, non-esterified fatty acids (NEFA), and of the acute phase protein haptoglobin was measured in all dogs. The CIBDAI scores decreased during the treatment period in FRD and IBD (P < 0.05). IGF-1 concentrations were positively correlated with body weight (BW) (rsp = 0.65, P < 0.001) and values of IGF-1 were therefore normalized with BW. IGF-1/BW ratios were lower in FRD and IBD before treatment than in C (P < 0.01). IGF-1/BW ratios increased in FRD (P < 0.05) dogs during treatment. Plasma glucose concentration was lower in FRD dogs before treatment than in C (P < 0.05), and NEFA concentrations were higher in FRDdogs before and after treatment than in C (P < 0.001). Haptoglobin concentrations were higher in IBD dogs before and after treatment than in all other groups (P < 0.05). In conclusion, chronic enteropathies reduce the plasma IGF-1 status in dogs. The increase of the IGF-1/BW ratio after treatment suggests that plasma IGF-1 concentration may help to judge the outcome of chronic enteropathies in dogs. |
| first_indexed | 2024-04-10T08:02:39Z |
| format | Article |
| id | doaj.art-1f1b88066ff64fa3a92104576377ef9a |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-04-10T08:02:39Z |
| publishDate | 2006-01-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-1f1b88066ff64fa3a92104576377ef9a2023-02-23T03:49:21ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922006-01-01511354310.17221/5515-VETMEDvet-200601-0005Plasma insulin-like growth factor-1 concentration in dogs with chronic enteropathiesA.C. Spichiger0K. Allenspach1Y. Zbinden2M.G. Doherr3S. Hiss4J.W. Blum5S.N. Sauter6Division of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing,Department of Clinical Veterinary Medicine, University of Bern, Bern, SwitzerlandDivision of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing,Department of Clinical Veterinary Medicine, University of Bern, Bern, SwitzerlandInstitute of Animal Science, Physiology and Hygiene, University of Bonn, Bonn, GermanyDivision of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing,Division of Nutrition and Physiology, Institute of Animal Genetics, Nutrition and Housing,Plasma concentrations of insulin-like growth factor (IGF)-1 were examined in dogs suffering from food-responsive diarrhea (group FRD) or inflammatory bowel disease (group IBD) before and after treatment and compared with IGF-1 values in healthy dogs (group C). Blood of 76 dogs was sampled (FRDbefore treatment, n = 23; IBD before treatment, n = 11; C, n = 42) and after treatment (FRD, n = 15; IBD, n= 8) with a hypoallergenic diet combined with (group IBD) or without prednisolone (group FRD). A clinical score (Canine IBD Activity Index = CIBDAI) was applied to judge the health status in all dogs. Plasma concentration of IGF-1, of total protein, albumin, glucose, urea, non-esterified fatty acids (NEFA), and of the acute phase protein haptoglobin was measured in all dogs. The CIBDAI scores decreased during the treatment period in FRD and IBD (P < 0.05). IGF-1 concentrations were positively correlated with body weight (BW) (rsp = 0.65, P < 0.001) and values of IGF-1 were therefore normalized with BW. IGF-1/BW ratios were lower in FRD and IBD before treatment than in C (P < 0.01). IGF-1/BW ratios increased in FRD (P < 0.05) dogs during treatment. Plasma glucose concentration was lower in FRD dogs before treatment than in C (P < 0.05), and NEFA concentrations were higher in FRDdogs before and after treatment than in C (P < 0.001). Haptoglobin concentrations were higher in IBD dogs before and after treatment than in all other groups (P < 0.05). In conclusion, chronic enteropathies reduce the plasma IGF-1 status in dogs. The increase of the IGF-1/BW ratio after treatment suggests that plasma IGF-1 concentration may help to judge the outcome of chronic enteropathies in dogs.https://vetmed.agriculturejournals.cz/artkey/vet-200601-0005_plasma-insulin-like-growth-factor-1-concentration-in-dogs-with-chronic-enteropathies.phpplasma insulin-like growth factormetaboliteshaptoglobinfood responsive diarrheainflammatory bowel disease |
| spellingShingle | A.C. Spichiger K. Allenspach Y. Zbinden M.G. Doherr S. Hiss J.W. Blum S.N. Sauter Plasma insulin-like growth factor-1 concentration in dogs with chronic enteropathies Veterinární Medicína plasma insulin-like growth factor metabolites haptoglobin food responsive diarrhea inflammatory bowel disease |
| title | Plasma insulin-like growth factor-1 concentration in dogs with chronic enteropathies |
| title_full | Plasma insulin-like growth factor-1 concentration in dogs with chronic enteropathies |
| title_fullStr | Plasma insulin-like growth factor-1 concentration in dogs with chronic enteropathies |
| title_full_unstemmed | Plasma insulin-like growth factor-1 concentration in dogs with chronic enteropathies |
| title_short | Plasma insulin-like growth factor-1 concentration in dogs with chronic enteropathies |
| title_sort | plasma insulin like growth factor 1 concentration in dogs with chronic enteropathies |
| topic | plasma insulin-like growth factor metabolites haptoglobin food responsive diarrhea inflammatory bowel disease |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-200601-0005_plasma-insulin-like-growth-factor-1-concentration-in-dogs-with-chronic-enteropathies.php |
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