Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription
<p>Ozone therapy is a modestly invasive procedure based on the regeneration capabilities of low ozone concentrations and used in medicine as an alternative/adjuvant treatment for different diseases. However, the cellular mechanisms accounting for the positive effects of mild ozonization are st...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2015-04-01
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| Series: | European Journal of Histochemistry |
| Subjects: | |
| Online Access: | http://ejh.it/index.php/ejh/article/view/2515 |
| _version_ | 1828234658330968064 |
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| author | M. Costanzo B. Cisterna A. Vella T. Cestari V. Covi G. Tabaracci M. Malatesta |
| author_facet | M. Costanzo B. Cisterna A. Vella T. Cestari V. Covi G. Tabaracci M. Malatesta |
| author_sort | M. Costanzo |
| collection | DOAJ |
| description | <p>Ozone therapy is a modestly invasive procedure based on the regeneration capabilities of low ozone concentrations and used in medicine as an alternative/adjuvant treatment for different diseases. However, the cellular mechanisms accounting for the positive effects of mild ozonization are still largely unexplored. To this aim, in the present study the effects of low ozone concentrations (1 to 20 µg O<sub>3</sub>/mL O<sub>2</sub>) on structural and functional cell features have been investigated <em>in vitro</em> by using morphological, morphometrical, cytochemical and immunocytochemical techniques at bright field, fluorescence and transmission electron microscopy. Cells exposed to pure O<sub>2</sub> or air served as controls. The results demonstrated that the effects of ozoneadministration are dependent on gas concentration, and the cytoskeletal organization, mitochondrial activity and nuclear transcription may be differently affected. This suggests that, to ensure effective and permanent metabolic cell activation, ozone treatments should take into account the cytological and cytokinetic features of the different tissues. </p> |
| first_indexed | 2024-04-12T19:59:46Z |
| format | Article |
| id | doaj.art-1f1cc17a7a6a4f169d61fb2530e501b0 |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-04-12T19:59:46Z |
| publishDate | 2015-04-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-1f1cc17a7a6a4f169d61fb2530e501b02022-12-22T03:18:35ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062015-04-0159210.4081/ejh.2015.25151454Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcriptionM. Costanzo0B. Cisterna1A. Vella2T. Cestari3V. Covi4G. Tabaracci5M. Malatesta6University of VeronaUniversity of VeronaUniversity of VeronaUniversity of VeronaSan Rocco ClinicSan Rocco ClinicUniversity of Verona<p>Ozone therapy is a modestly invasive procedure based on the regeneration capabilities of low ozone concentrations and used in medicine as an alternative/adjuvant treatment for different diseases. However, the cellular mechanisms accounting for the positive effects of mild ozonization are still largely unexplored. To this aim, in the present study the effects of low ozone concentrations (1 to 20 µg O<sub>3</sub>/mL O<sub>2</sub>) on structural and functional cell features have been investigated <em>in vitro</em> by using morphological, morphometrical, cytochemical and immunocytochemical techniques at bright field, fluorescence and transmission electron microscopy. Cells exposed to pure O<sub>2</sub> or air served as controls. The results demonstrated that the effects of ozoneadministration are dependent on gas concentration, and the cytoskeletal organization, mitochondrial activity and nuclear transcription may be differently affected. This suggests that, to ensure effective and permanent metabolic cell activation, ozone treatments should take into account the cytological and cytokinetic features of the different tissues. </p>http://ejh.it/index.php/ejh/article/view/2515Ozonein vitro cultureepithelial cellscell nucleuscytoskeletonmitochondriaheat shock proteins |
| spellingShingle | M. Costanzo B. Cisterna A. Vella T. Cestari V. Covi G. Tabaracci M. Malatesta Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription European Journal of Histochemistry Ozone in vitro culture epithelial cells cell nucleus cytoskeleton mitochondria heat shock proteins |
| title | Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription |
| title_full | Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription |
| title_fullStr | Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription |
| title_full_unstemmed | Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription |
| title_short | Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription |
| title_sort | low ozone concentrations stimulate cytoskeletal organization mitochondrial activity and nuclear transcription |
| topic | Ozone in vitro culture epithelial cells cell nucleus cytoskeleton mitochondria heat shock proteins |
| url | http://ejh.it/index.php/ejh/article/view/2515 |
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