Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

The recent cryo-electron microscopy structures of zebrafish and the human cystic fibrosis transmembrane conductance regulator (CFTR) provided unprecedented insights into putative mechanisms underlying gating of its anion channel activity. Interestingly, despite predictions based on channel activity...

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Bibliographic Details
Main Authors: Stephanie Chin, Mohabir Ramjeesingh, Maurita Hung, June Ereño-Oreba, Hong Cui, Onofrio Laselva, Jean-Philippe Julien, Christine E. Bear
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cells
Subjects:
membrane protein purification
amphipol:A8-35
intrinsic anion channel activity
catalytic activity
proteoliposomal flux
functional reconstitution
Online Access:https://www.mdpi.com/2073-4409/8/8/804

Internet

https://www.mdpi.com/2073-4409/8/8/804

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