Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study
Colorectal adenoma is linked to metabolic dysfunction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has a precise definition and three subtypes, including non-obese MAFLD. We aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to non-alcoh...
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/5462 |
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| author | Shuhei Fukunaga Dan Nakano Takumi Kawaguchi Mohammed Eslam Akihiro Ouchi Tsutomu Nagata Hidefumi Kuroki Hidemichi Kawata Hirohiko Abe Ryuichi Nouno Koutaro Kawaguchi Jacob George Keiichi Mitsuyama Takuji Torimura |
| author_facet | Shuhei Fukunaga Dan Nakano Takumi Kawaguchi Mohammed Eslam Akihiro Ouchi Tsutomu Nagata Hidefumi Kuroki Hidemichi Kawata Hirohiko Abe Ryuichi Nouno Koutaro Kawaguchi Jacob George Keiichi Mitsuyama Takuji Torimura |
| author_sort | Shuhei Fukunaga |
| collection | DOAJ |
| description | Colorectal adenoma is linked to metabolic dysfunction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has a precise definition and three subtypes, including non-obese MAFLD. We aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to non-alcoholic fatty liver disease (NAFLD) in health check-up examinees. This is a multicenter retrospective study. We enrolled 124 consecutive health check-up examinees who underwent colonoscopy. NAFLD and MAFLD were present in 58 and 63 examinees, respectively. Colorectal adenoma was diagnosed by biopsy. The impact of the MAFLD definition on the prevalence of colorectal adenoma was investigated by logistic regression, decision-tree, and random forest analyses. In logistic regression analysis, MAFLD was identified as the only independent factor associated with the presence of colorectal adenoma (OR 3.191; 95% CI 1.494–7.070; <i>p</i> = 0.003). MAFLD was also identified as the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (29 variable importance value). Among the three subtypes of MAFLD, non-obese MAFLD was the sole independent factor associated with the presence of colorectal adenoma (OR 3.351; 95% CI 1.589–7.262; <i>p</i> ≤ 0.001). Non-obese MAFLD was also the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (31 variable importance value). MAFLD, particularly non-obese MAFLD, is the most important factor associated with the presence of colorectal adenoma rather than NAFLD. Colonoscopy examination should be considered in patients with MAFLD, especially those who are non-obese. |
| first_indexed | 2024-03-10T11:09:02Z |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:09:02Z |
| publishDate | 2021-05-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1f1f5e8addda4b21816ea7806847789b2023-11-21T20:53:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012211546210.3390/ijms22115462Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective StudyShuhei Fukunaga0Dan Nakano1Takumi Kawaguchi2Mohammed Eslam3Akihiro Ouchi4Tsutomu Nagata5Hidefumi Kuroki6Hidemichi Kawata7Hirohiko Abe8Ryuichi Nouno9Koutaro Kawaguchi10Jacob George11Keiichi Mitsuyama12Takuji Torimura13Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, JapanStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, 176 Hawkesbury Rd, Westmead, NSW 2145, AustraliaDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, JapanDiagnostic Imaging Center, Kurume University Hospital, 67 Asahi-machi, Kurume 830-0011, JapanDiagnostic Imaging Center, Kurume University Hospital, 67 Asahi-machi, Kurume 830-0011, JapanDepartment of Gastroenterology, Kumamoto Central Hospital, 2921 Haramizu, Kikuyo, Kikuchi 869-1102, JapanDepartment of Gastroenterology, Kumamoto Central Hospital, 2921 Haramizu, Kikuyo, Kikuchi 869-1102, JapanKurate Hospital, 2425-9 Nakayama Kurate-machi, Kurate 807-1312, JapanStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, 176 Hawkesbury Rd, Westmead, NSW 2145, AustraliaDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, JapanColorectal adenoma is linked to metabolic dysfunction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has a precise definition and three subtypes, including non-obese MAFLD. We aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to non-alcoholic fatty liver disease (NAFLD) in health check-up examinees. This is a multicenter retrospective study. We enrolled 124 consecutive health check-up examinees who underwent colonoscopy. NAFLD and MAFLD were present in 58 and 63 examinees, respectively. Colorectal adenoma was diagnosed by biopsy. The impact of the MAFLD definition on the prevalence of colorectal adenoma was investigated by logistic regression, decision-tree, and random forest analyses. In logistic regression analysis, MAFLD was identified as the only independent factor associated with the presence of colorectal adenoma (OR 3.191; 95% CI 1.494–7.070; <i>p</i> = 0.003). MAFLD was also identified as the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (29 variable importance value). Among the three subtypes of MAFLD, non-obese MAFLD was the sole independent factor associated with the presence of colorectal adenoma (OR 3.351; 95% CI 1.589–7.262; <i>p</i> ≤ 0.001). Non-obese MAFLD was also the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (31 variable importance value). MAFLD, particularly non-obese MAFLD, is the most important factor associated with the presence of colorectal adenoma rather than NAFLD. Colonoscopy examination should be considered in patients with MAFLD, especially those who are non-obese.https://www.mdpi.com/1422-0067/22/11/5462colorectal neoplasmsmetabolic syndromenon-alcoholic fatty liver diseasethinnessliver steatosis |
| spellingShingle | Shuhei Fukunaga Dan Nakano Takumi Kawaguchi Mohammed Eslam Akihiro Ouchi Tsutomu Nagata Hidefumi Kuroki Hidemichi Kawata Hirohiko Abe Ryuichi Nouno Koutaro Kawaguchi Jacob George Keiichi Mitsuyama Takuji Torimura Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study International Journal of Molecular Sciences colorectal neoplasms metabolic syndrome non-alcoholic fatty liver disease thinness liver steatosis |
| title | Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study |
| title_full | Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study |
| title_fullStr | Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study |
| title_full_unstemmed | Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study |
| title_short | Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study |
| title_sort | non obese mafld is associated with colorectal adenoma in health check examinees a multicenter retrospective study |
| topic | colorectal neoplasms metabolic syndrome non-alcoholic fatty liver disease thinness liver steatosis |
| url | https://www.mdpi.com/1422-0067/22/11/5462 |
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