Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast
Cells have developed response systems to constantly monitor environmental changes and accordingly adjust growth, differentiation, and cellular stress programs. The evolutionarily conserved, nutrient-responsive, mechanistic target of rapamycin signaling (mTOR) pathway coordinates basic anabolic and c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/2/305 |
| _version_ | 1797416346556825600 |
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| author | John-Patrick Alao Luc Legon Charalampos Rallis |
| author_facet | John-Patrick Alao Luc Legon Charalampos Rallis |
| author_sort | John-Patrick Alao |
| collection | DOAJ |
| description | Cells have developed response systems to constantly monitor environmental changes and accordingly adjust growth, differentiation, and cellular stress programs. The evolutionarily conserved, nutrient-responsive, mechanistic target of rapamycin signaling (mTOR) pathway coordinates basic anabolic and catabolic cellular processes such as gene transcription, protein translation, autophagy, and metabolism, and is directly implicated in cellular and organismal aging as well as age-related diseases. mTOR mediates these processes in response to a broad range of inputs such as oxygen, amino acids, hormones, and energy levels, as well as stresses, including DNA damage. Here, we briefly summarize data relating to the interplays of the mTOR pathway with DNA damage response pathways in fission yeast, a favorite model in cell biology, and how these interactions shape cell decisions, growth, and cell-cycle progression. We, especially, comment on the roles of caffeine-mediated DNA-damage override. Understanding the biology of nutrient response, DNA damage and related pharmacological treatments can lead to the design of interventions towards improved cellular and organismal fitness, health, and survival. |
| first_indexed | 2024-03-09T06:01:59Z |
| format | Article |
| id | doaj.art-1f20726cf272499e9932739ceea54605 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T06:01:59Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1f20726cf272499e9932739ceea546052023-12-03T12:07:26ZengMDPI AGCells2073-44092021-02-0110230510.3390/cells10020305Crosstalk between the mTOR and DNA Damage Response Pathways in Fission YeastJohn-Patrick Alao0Luc Legon1Charalampos Rallis2ZEAB Therapeutic, University of East London, Stratford Campus, Water Lane, Stratford, London E15 4LZ, UKSchool of Health, Sport and Bioscience, University of East London, Stratford Campus, Water Lane, Stratford, London E15 4LZ, UKSchool of Life Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UKCells have developed response systems to constantly monitor environmental changes and accordingly adjust growth, differentiation, and cellular stress programs. The evolutionarily conserved, nutrient-responsive, mechanistic target of rapamycin signaling (mTOR) pathway coordinates basic anabolic and catabolic cellular processes such as gene transcription, protein translation, autophagy, and metabolism, and is directly implicated in cellular and organismal aging as well as age-related diseases. mTOR mediates these processes in response to a broad range of inputs such as oxygen, amino acids, hormones, and energy levels, as well as stresses, including DNA damage. Here, we briefly summarize data relating to the interplays of the mTOR pathway with DNA damage response pathways in fission yeast, a favorite model in cell biology, and how these interactions shape cell decisions, growth, and cell-cycle progression. We, especially, comment on the roles of caffeine-mediated DNA-damage override. Understanding the biology of nutrient response, DNA damage and related pharmacological treatments can lead to the design of interventions towards improved cellular and organismal fitness, health, and survival.https://www.mdpi.com/2073-4409/10/2/305TORC1TORC2nutrientscaffeinerapamycinRad3 |
| spellingShingle | John-Patrick Alao Luc Legon Charalampos Rallis Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast Cells TORC1 TORC2 nutrients caffeine rapamycin Rad3 |
| title | Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast |
| title_full | Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast |
| title_fullStr | Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast |
| title_full_unstemmed | Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast |
| title_short | Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast |
| title_sort | crosstalk between the mtor and dna damage response pathways in fission yeast |
| topic | TORC1 TORC2 nutrients caffeine rapamycin Rad3 |
| url | https://www.mdpi.com/2073-4409/10/2/305 |
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