Philippine retinoblastoma initiative multi-eye center study 2010-2020
AIM: To provide a comprehensive and more representative national data on the disease, especially on treatment options and outcomes, and to determine access of retinoblastoma patients from Luzon, Visayas and Mindanao to eye care, and determine if access is associated with delay in consultation, stagi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2024-01-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/en_publish/2024/1/20240120.pdf |
| _version_ | 1797376268562333696 |
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| author | Roland Joseph D. Tan Gary John V. Mercado Patricia E. Cabrera Paulita Pamela P. Astudillo Rolando Enrique D. Domingo Josept Mari S. Poblete Charmaine Grace M. Cabebe Adriel Vincent R. Te Melissa Anne S. Gonzales Jocelyn G. Sy Beltran Alexis A. Aclan Jayson T. So Fatima G. Regala Kimberley Amanda K. Comia Josemaria M. Castro Mara Augustine S. Galang Aldous Dominic C. Cabanlas Benedicto Juan E. Aguilar Gabrielle S. Evangelista Jo Michael Maniwan Andrei P. Martin Calvin Y. Martinez John Alfred H. Lim Rena Ivy Bascuna Rachel M. Ng Kevin B. Agsaoay Kris Zanna A. Acluba-Arao Ellaine Rose V. Apostol Beatriz M. Prieto |
| author_facet | Roland Joseph D. Tan Gary John V. Mercado Patricia E. Cabrera Paulita Pamela P. Astudillo Rolando Enrique D. Domingo Josept Mari S. Poblete Charmaine Grace M. Cabebe Adriel Vincent R. Te Melissa Anne S. Gonzales Jocelyn G. Sy Beltran Alexis A. Aclan Jayson T. So Fatima G. Regala Kimberley Amanda K. Comia Josemaria M. Castro Mara Augustine S. Galang Aldous Dominic C. Cabanlas Benedicto Juan E. Aguilar Gabrielle S. Evangelista Jo Michael Maniwan Andrei P. Martin Calvin Y. Martinez John Alfred H. Lim Rena Ivy Bascuna Rachel M. Ng Kevin B. Agsaoay Kris Zanna A. Acluba-Arao Ellaine Rose V. Apostol Beatriz M. Prieto |
| author_sort | Roland Joseph D. Tan |
| collection | DOAJ |
| description | AIM: To provide a comprehensive and more representative national data on the disease, especially on treatment options and outcomes, and to determine access of retinoblastoma patients from Luzon, Visayas and Mindanao to eye care, and determine if access is associated with delay in consultation, staging and outcomes. METHODS: Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon, Vizayas and Mindanao from 2010-2020. RESULTS: Totally 636 patients, involving 821 eyes, were included. Majority (57%) were from Luzon and were seen in institutions in Luzon (72%). Annually, 58±10 new cases were seen with 71% having unilateral disease. Median delay of consultation remained long at 9 (3, 17)mo, longest in patients with unilateral disease (P<0.02) and those from the Visayas (P<0.003). Based on the International Retinoblastoma Staging System, only 35% of patients had Stage 1 while 47% already had extraocular disease. Enucleation was the most common treatment received by 484 patients while intravenous chemotherapy was received by 469. There were 250 (39%) patients alive, 195 (31%) dead, 85 (13%) abandoned, 17 (3%) refused and 89 (14%) with no data. CONCLUSION: This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients' and participating institutions' number and geographical location and type of institution (private and public). It also presents more comprehensive data on the treatments used and outcomes (survival, globe salvage, and vision retention rates). Delay in consultation was still long among patients leading to advanced disease stage and lower survival rate. Despite increasing capacity to diagnose and manage retinoblastoma in the country, the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial concerns. The delay was still significant that overall survival rate remain low. |
| first_indexed | 2024-03-08T19:36:05Z |
| format | Article |
| id | doaj.art-1f2161344ff041b6b6466ca2ff49ce42 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-03-08T19:36:05Z |
| publishDate | 2024-01-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-1f2161344ff041b6b6466ca2ff49ce422023-12-26T01:50:00ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982024-01-0117114415610.18240/ijo.2024.01.2020240120Philippine retinoblastoma initiative multi-eye center study 2010-2020Roland Joseph D. Tan0Gary John V. Mercado1Patricia E. Cabrera2Paulita Pamela P. Astudillo3Rolando Enrique D. Domingo4Josept Mari S. Poblete5Charmaine Grace M. Cabebe6Adriel Vincent R. Te7Melissa Anne S. Gonzales8Jocelyn G. Sy9Beltran Alexis A. Aclan10Jayson T. So11Fatima G. Regala12Kimberley Amanda K. Comia13Josemaria M. Castro14Mara Augustine S. Galang15Aldous Dominic C. Cabanlas16Benedicto Juan E. Aguilar17Gabrielle S. Evangelista18Jo Michael Maniwan19Andrei P. Martin20Calvin Y. Martinez21John Alfred H. Lim22Rena Ivy Bascuna23Rachel M. Ng24Kevin B. Agsaoay25Kris Zanna A. Acluba-Arao26Ellaine Rose V. Apostol27Beatriz M. Prieto28Roland Joseph D. Tan. Department of Ophthalmology and Visual Sciences, Sentro Oftalmogico Jose Rizal, Philippine General Hospital, Padre Faura Street, Ermita, Manila 1000, Philippines. olantan385e@yahoo.comDepartment of Ophthalmology and Visual Sciences, Philippine General Hospital, Manila 1000, Philippines; Department of Ophthalmology, Manila Doctors Hospital, Manila 1000, PhilippinesDepartment of Ophthalmology and Visual Sciences, Philippine General Hospital, Manila 1000, Philippines; Department of Ophthalmology, Rizal Medical Center, Pasig City 1600, PhilippinesDepartment of Ophthalmology and Visual Sciences, Philippine General Hospital, Manila 1000, Philippines; Department of Ophthalmology, Jose B. Lingad Memorial Regional Hospital, Pampanga 2000, PhilippinesDepartment of Ophthalmology and Visual Sciences, Philippine General Hospital, Manila 1000, PhilippinesDepartment of Ophthalmology and Visual Sciences, Philippine General Hospital, Manila 1000, PhilippinesDepartment of Ophthalmology, Southern Philippines Medical Center, Davao City 8000, PhilippinesDepartment of Ophthalmology, Southern Philippines Medical Center, Davao City 8000, PhilippinesDepartment of Ophthalmology, Southern Philippines Medical Center, Davao City 8000, PhilippinesDepartment of Ophthalmology, Southern Philippines Medical Center, Davao City 8000, PhilippinesDepartment of Ophthalmology, East Avenue Medical Center, Quezon City 1100, PhilippinesDepartment of Ophthalmology, East Avenue Medical Center, Quezon City 1100, PhilippinesDepartment of Ophthalmology, East Avenue Medical Center, Quezon City 1100, PhilippinesDepartment of Ophthalmology, Manila Doctors Hospital, Manila 1000, PhilippinesDepartment of Ophthalmology, Manila Doctors Hospital, Manila 1000, PhilippinesDepartment of Ophthalmology, Manila Doctors Hospital, Manila 1000, PhilippinesDepartment of Ophthalmology, Northern Mindanao Medical Center, Cagayan de Oro City 9000, PhilippinesDepartment of Ophthalmology, Northern Mindanao Medical Center, Cagayan de Oro City 9000, PhilippinesDepartment of Ophthalmology, Northern Mindanao Medical Center, Cagayan de Oro City 9000, PhilippinesDepartment of Ophthalmology, Rizal Medical Center, Pasig City 1600, PhilippinesDepartment of Ophthalmology, Rizal Medical Center, Pasig City 1600, PhilippinesDepartment of Ophthalmology, Cebu Velez General Hospital, Cebu City 6000, PhilippinesDepartment of Ophthalmology, Cebu Velez General Hospital, Cebu City 6000, PhilippinesLegazpi Eye Center, Legazpi City 4500, PhilippinesLegazpi Eye Center, Legazpi City 4500, PhilippinesDepartment of Ophthalmology, Cagayan Valley Medical Center, Tuguegarao City 3500, PhilippinesDepartment of Ophthalmology, Cagayan Valley Medical Center, Tuguegarao City 3500, PhilippinesDepartment of Ophthalmology, East Avenue Medical Center, Quezon City 1100, PhilippinesDepartment of Ophthalmology, East Avenue Medical Center, Quezon City 1100, PhilippinesAIM: To provide a comprehensive and more representative national data on the disease, especially on treatment options and outcomes, and to determine access of retinoblastoma patients from Luzon, Visayas and Mindanao to eye care, and determine if access is associated with delay in consultation, staging and outcomes. METHODS: Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon, Vizayas and Mindanao from 2010-2020. RESULTS: Totally 636 patients, involving 821 eyes, were included. Majority (57%) were from Luzon and were seen in institutions in Luzon (72%). Annually, 58±10 new cases were seen with 71% having unilateral disease. Median delay of consultation remained long at 9 (3, 17)mo, longest in patients with unilateral disease (P<0.02) and those from the Visayas (P<0.003). Based on the International Retinoblastoma Staging System, only 35% of patients had Stage 1 while 47% already had extraocular disease. Enucleation was the most common treatment received by 484 patients while intravenous chemotherapy was received by 469. There were 250 (39%) patients alive, 195 (31%) dead, 85 (13%) abandoned, 17 (3%) refused and 89 (14%) with no data. CONCLUSION: This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients' and participating institutions' number and geographical location and type of institution (private and public). It also presents more comprehensive data on the treatments used and outcomes (survival, globe salvage, and vision retention rates). Delay in consultation was still long among patients leading to advanced disease stage and lower survival rate. Despite increasing capacity to diagnose and manage retinoblastoma in the country, the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial concerns. The delay was still significant that overall survival rate remain low.http://ies.ijo.cn/en_publish/2024/1/20240120.pdfretinoblastomaphilippinesclinical profile |
| spellingShingle | Roland Joseph D. Tan Gary John V. Mercado Patricia E. Cabrera Paulita Pamela P. Astudillo Rolando Enrique D. Domingo Josept Mari S. Poblete Charmaine Grace M. Cabebe Adriel Vincent R. Te Melissa Anne S. Gonzales Jocelyn G. Sy Beltran Alexis A. Aclan Jayson T. So Fatima G. Regala Kimberley Amanda K. Comia Josemaria M. Castro Mara Augustine S. Galang Aldous Dominic C. Cabanlas Benedicto Juan E. Aguilar Gabrielle S. Evangelista Jo Michael Maniwan Andrei P. Martin Calvin Y. Martinez John Alfred H. Lim Rena Ivy Bascuna Rachel M. Ng Kevin B. Agsaoay Kris Zanna A. Acluba-Arao Ellaine Rose V. Apostol Beatriz M. Prieto Philippine retinoblastoma initiative multi-eye center study 2010-2020 International Journal of Ophthalmology retinoblastoma philippines clinical profile |
| title | Philippine retinoblastoma initiative multi-eye center study 2010-2020 |
| title_full | Philippine retinoblastoma initiative multi-eye center study 2010-2020 |
| title_fullStr | Philippine retinoblastoma initiative multi-eye center study 2010-2020 |
| title_full_unstemmed | Philippine retinoblastoma initiative multi-eye center study 2010-2020 |
| title_short | Philippine retinoblastoma initiative multi-eye center study 2010-2020 |
| title_sort | philippine retinoblastoma initiative multi eye center study 2010 2020 |
| topic | retinoblastoma philippines clinical profile |
| url | http://ies.ijo.cn/en_publish/2024/1/20240120.pdf |
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