Inhibiting uptake of extracellular vesicles derived from senescent bone marrow mesenchymal stem cells by muscle satellite cells attenuates sarcopenia

Inhibiting uptake of extracellular vesicles derived from senescent bone marrow mesenchymal stem cells by muscle satellite cells attenuates sarcopenia

Objective: Osteoporosis is associated with senescence of bone marrow mesenchymal stem cells (BMSCs). Extracellular vesicles derived from senescent BMSCs (BMSC-EVs) could be uptaken by muscle satellite cells (SCs). We hypothesized that inhibiting the uptake of harmful BMSC-EVs by SCs could prevent pa...

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Bibliographic Details
Main Authors: Hanhao Dai, Wu Zheng, Jun Luo, Guoyu Yu, Chao Song, Yijing Wu, Jie Xu
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Journal of Orthopaedic Translation
Subjects:
Sarcopenia
Osteoporosis
Senescence
Extracellular vesicles
CD81
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X22000523

Internet

http://www.sciencedirect.com/science/article/pii/S2214031X22000523

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