Regulation of the Mitochondrion-Fatty Acid Axis for the Metabolic Reprogramming of <named-content content-type="genus-species">Chlamydia trachomatis</named-content> during Treatment with β-Lactam Antimicrobials

Regulation of the Mitochondrion-Fatty Acid Axis for the Metabolic Reprogramming of <named-content content-type="genus-species">Chlamydia trachomatis</named-content> during Treatment with β-Lactam Antimicrobials

ABSTRACT Infection with the obligate intracellular bacterium Chlamydia trachomatis is the most common bacterial sexually transmitted disease worldwide. Since no vaccine is available to date, antimicrobial therapy is the only alternative in C. trachomatis infection. However, changes in chlamydial rep...

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Bibliographic Details
Main Authors: Kensuke Shima, Inga Kaufhold, Thomas Eder, Nadja Käding, Nis Schmidt, Iretiolu M. Ogunsulire, René Deenen, Karl Köhrer, Dirk Friedrich, Sophie E. Isay, Florian Grebien, Matthias Klinger, Barbara C. Richer, Ulrich L. Günther, George S. Deepe, Thomas Rattei, Jan Rupp
Format: Article
Language:English
Published: American Society for Microbiology 2021-04-01
Series:mBio
Subjects:
Chlamydia trachomatis
citrate
STAT3
beta-lactams
fatty acids
metabolism
Online Access:https://journals.asm.org/doi/10.1128/mBio.00023-21

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