Alveolus Lung-on-a-Chip Platform: A Proposal
Respiratory diseases are top-ranked causes of deaths and disabilities around the world, making new approaches to the treatment necessary. In recent years, lung-on-a-chip platforms have emerged as a potential candidate to replace animal experiments because they can successfully simulate human physiol...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
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| Series: | Chemosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9040/9/9/248 |
| _version_ | 1797519812074668032 |
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| author | Noelia Campillo Vinicius Rosa Oliveira Renata Kelly da Palma |
| author_facet | Noelia Campillo Vinicius Rosa Oliveira Renata Kelly da Palma |
| author_sort | Noelia Campillo |
| collection | DOAJ |
| description | Respiratory diseases are top-ranked causes of deaths and disabilities around the world, making new approaches to the treatment necessary. In recent years, lung-on-a-chip platforms have emerged as a potential candidate to replace animal experiments because they can successfully simulate human physiology. In this review, we discuss the main respiratory diseases and their pathophysiology, how to model a lung microenvironment, and how to translate it to clinical applications. Furthermore, we propose a novel alveolus lung-on-a-chip platform, based on all currently available methodologies. This review provides solutions and new ideas to improve the alveolar lung-on-a-chip platform. Finally, we provided evidence that approaches such as 3D printing, organ-a-chip devices and organoids can be used in combination, and some challenges could be overcome. |
| first_indexed | 2024-03-10T07:48:04Z |
| format | Article |
| id | doaj.art-1f222b50061d4af392eb33ad36ae0940 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-10T07:48:04Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-1f222b50061d4af392eb33ad36ae09402023-11-22T12:28:38ZengMDPI AGChemosensors2227-90402021-09-019924810.3390/chemosensors9090248Alveolus Lung-on-a-Chip Platform: A ProposalNoelia Campillo0Vinicius Rosa Oliveira1Renata Kelly da Palma2BRECA Health Care SL, 18016 Granada, SpainResearch Group on Methodology, Methods, Models and Outcomes of Health and Social Sciences (M3O), University of Vic-Central University of Catalonia, 08500 Vic, SpainDepartment of Physical Therapy, EUSES University School, University of Barcelona-University of Girona (UB-UdG), 08907 Barcelona, SpainRespiratory diseases are top-ranked causes of deaths and disabilities around the world, making new approaches to the treatment necessary. In recent years, lung-on-a-chip platforms have emerged as a potential candidate to replace animal experiments because they can successfully simulate human physiology. In this review, we discuss the main respiratory diseases and their pathophysiology, how to model a lung microenvironment, and how to translate it to clinical applications. Furthermore, we propose a novel alveolus lung-on-a-chip platform, based on all currently available methodologies. This review provides solutions and new ideas to improve the alveolar lung-on-a-chip platform. Finally, we provided evidence that approaches such as 3D printing, organ-a-chip devices and organoids can be used in combination, and some challenges could be overcome.https://www.mdpi.com/2227-9040/9/9/248lung diseasemicrofluidicorgan-on-a-chip |
| spellingShingle | Noelia Campillo Vinicius Rosa Oliveira Renata Kelly da Palma Alveolus Lung-on-a-Chip Platform: A Proposal Chemosensors lung disease microfluidic organ-on-a-chip |
| title | Alveolus Lung-on-a-Chip Platform: A Proposal |
| title_full | Alveolus Lung-on-a-Chip Platform: A Proposal |
| title_fullStr | Alveolus Lung-on-a-Chip Platform: A Proposal |
| title_full_unstemmed | Alveolus Lung-on-a-Chip Platform: A Proposal |
| title_short | Alveolus Lung-on-a-Chip Platform: A Proposal |
| title_sort | alveolus lung on a chip platform a proposal |
| topic | lung disease microfluidic organ-on-a-chip |
| url | https://www.mdpi.com/2227-9040/9/9/248 |
| work_keys_str_mv | AT noeliacampillo alveoluslungonachipplatformaproposal AT viniciusrosaoliveira alveoluslungonachipplatformaproposal AT renatakellydapalma alveoluslungonachipplatformaproposal |