Bacterial Cellulose—Adaptation of a Nature-Identical Material to the Needs of Advanced Chronic Wound Care
Modern wound treatment calls for hydroactive dressings. Among the variety of materials that have entered the field of wound care in recent years, the carbohydrate polymer bacterial cellulose (BC) represents one of the most promising candidates as the biomaterial features a high moisture-loading and...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/15/6/683 |
| _version_ | 1797483382538502144 |
|---|---|
| author | Paul Zahel Uwe Beekmann Thomas Eberlein Michael Schmitz Oliver Werz Dana Kralisch |
| author_facet | Paul Zahel Uwe Beekmann Thomas Eberlein Michael Schmitz Oliver Werz Dana Kralisch |
| author_sort | Paul Zahel |
| collection | DOAJ |
| description | Modern wound treatment calls for hydroactive dressings. Among the variety of materials that have entered the field of wound care in recent years, the carbohydrate polymer bacterial cellulose (BC) represents one of the most promising candidates as the biomaterial features a high moisture-loading and donation capacity, mechanical stability, moldability, and breathability. Although BC has already gained increasing relevance in the treatment of burn wounds, its potential and clinical performance for “chronic wound” indications have not yet been sufficiently investigated. This article focuses on experimental and clinical data regarding the application of BC within the indications of chronic, non-healing wounds, especially venous and diabetic ulcers. A recent clinical observation study in a chronic wound setting clearly demonstrated its wound-cleansing properties and ability to induce healing in stalling wounds. Furthermore, the material parameters of BC dressings obtained through the static cultivation of <i>Komagataeibacter xylinus</i> were investigated for the first time in standardized tests and compared to various advanced wound-care products. Surprisingly, a free swell absorptive capacity of a BC dressing variant containing 97% moisture was found, which was higher than that of alginate or even hydrofiber dressings. We hypothesize that the fine-structured, open porous network and the resulting capillary forces are among the main reasons for this unexpected result. |
| first_indexed | 2024-03-09T22:47:09Z |
| format | Article |
| id | doaj.art-1f22b25ddcd64a09895e10b11e1559cd |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T22:47:09Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-1f22b25ddcd64a09895e10b11e1559cd2023-11-23T18:26:57ZengMDPI AGPharmaceuticals1424-82472022-05-0115668310.3390/ph15060683Bacterial Cellulose—Adaptation of a Nature-Identical Material to the Needs of Advanced Chronic Wound CarePaul Zahel0Uwe Beekmann1Thomas Eberlein2Michael Schmitz3Oliver Werz4Dana Kralisch5JeNaCell GmbH—An Evonik Company, 07745 Jena, GermanyJeNaCell GmbH—An Evonik Company, 07745 Jena, GermanyAkademie-ZWM AG, 8424 Embrach, SwitzerlandMCS Medical Consulting, 56414 Oberahr, GermanyDepartment of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, 07743 Jena, GermanyJeNaCell GmbH—An Evonik Company, 07745 Jena, GermanyModern wound treatment calls for hydroactive dressings. Among the variety of materials that have entered the field of wound care in recent years, the carbohydrate polymer bacterial cellulose (BC) represents one of the most promising candidates as the biomaterial features a high moisture-loading and donation capacity, mechanical stability, moldability, and breathability. Although BC has already gained increasing relevance in the treatment of burn wounds, its potential and clinical performance for “chronic wound” indications have not yet been sufficiently investigated. This article focuses on experimental and clinical data regarding the application of BC within the indications of chronic, non-healing wounds, especially venous and diabetic ulcers. A recent clinical observation study in a chronic wound setting clearly demonstrated its wound-cleansing properties and ability to induce healing in stalling wounds. Furthermore, the material parameters of BC dressings obtained through the static cultivation of <i>Komagataeibacter xylinus</i> were investigated for the first time in standardized tests and compared to various advanced wound-care products. Surprisingly, a free swell absorptive capacity of a BC dressing variant containing 97% moisture was found, which was higher than that of alginate or even hydrofiber dressings. We hypothesize that the fine-structured, open porous network and the resulting capillary forces are among the main reasons for this unexpected result.https://www.mdpi.com/1424-8247/15/6/683bacterial cellulosecarbohydrate polymeradvanced wound carechronic woundsclinical dataexudate management |
| spellingShingle | Paul Zahel Uwe Beekmann Thomas Eberlein Michael Schmitz Oliver Werz Dana Kralisch Bacterial Cellulose—Adaptation of a Nature-Identical Material to the Needs of Advanced Chronic Wound Care Pharmaceuticals bacterial cellulose carbohydrate polymer advanced wound care chronic wounds clinical data exudate management |
| title | Bacterial Cellulose—Adaptation of a Nature-Identical Material to the Needs of Advanced Chronic Wound Care |
| title_full | Bacterial Cellulose—Adaptation of a Nature-Identical Material to the Needs of Advanced Chronic Wound Care |
| title_fullStr | Bacterial Cellulose—Adaptation of a Nature-Identical Material to the Needs of Advanced Chronic Wound Care |
| title_full_unstemmed | Bacterial Cellulose—Adaptation of a Nature-Identical Material to the Needs of Advanced Chronic Wound Care |
| title_short | Bacterial Cellulose—Adaptation of a Nature-Identical Material to the Needs of Advanced Chronic Wound Care |
| title_sort | bacterial cellulose adaptation of a nature identical material to the needs of advanced chronic wound care |
| topic | bacterial cellulose carbohydrate polymer advanced wound care chronic wounds clinical data exudate management |
| url | https://www.mdpi.com/1424-8247/15/6/683 |
| work_keys_str_mv | AT paulzahel bacterialcelluloseadaptationofanatureidenticalmaterialtotheneedsofadvancedchronicwoundcare AT uwebeekmann bacterialcelluloseadaptationofanatureidenticalmaterialtotheneedsofadvancedchronicwoundcare AT thomaseberlein bacterialcelluloseadaptationofanatureidenticalmaterialtotheneedsofadvancedchronicwoundcare AT michaelschmitz bacterialcelluloseadaptationofanatureidenticalmaterialtotheneedsofadvancedchronicwoundcare AT oliverwerz bacterialcelluloseadaptationofanatureidenticalmaterialtotheneedsofadvancedchronicwoundcare AT danakralisch bacterialcelluloseadaptationofanatureidenticalmaterialtotheneedsofadvancedchronicwoundcare |