Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin
The objective of this study was to evaluate the intradermal delivery of curcumin utilising poly(vinylalcohol) (PVA)-based microneedles loaded with curcumin nanosuspension (CU-NS). Nanoprecipitation was used to formulate the CU-NS which was then incorporated into PVA microneedles arrays consisting of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/11/7/308 |
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| author | Sharif Abdelghany Ismaiel A. Tekko Lalitkumar Vora Eneko Larrañeta Andi Dian Permana Ryan F. Donnelly |
| author_facet | Sharif Abdelghany Ismaiel A. Tekko Lalitkumar Vora Eneko Larrañeta Andi Dian Permana Ryan F. Donnelly |
| author_sort | Sharif Abdelghany |
| collection | DOAJ |
| description | The objective of this study was to evaluate the intradermal delivery of curcumin utilising poly(vinylalcohol) (PVA)-based microneedles loaded with curcumin nanosuspension (CU-NS). Nanoprecipitation was used to formulate the CU-NS which was then incorporated into PVA microneedles arrays consisting of 11 × 11 microneedles of conical shape, measuring 900 µm in height and with 300 µm base diameter. The nanosuspension particle size was 520 ± 40 nm, with a polydispersity of 0.27 ± 0.02 using sodium lauryl sulfate (SLS) as a stabiliser. In vitro dissolution studies in 10% <i>w/v</i> Tween 80 showed that the CU-NS dissolved significantly faster than unmodified curcumin powder, with 34% released from the CU-NS, compared to 16% from the curcumin powder after 48 h. The CU-NS-loaded microneedles (CU-MN) were able to withstand a compression force of 32 N for 30 s. Moreover, these microneedles were able to penetrate excised neonatal porcine skin to a depth of 500 µm, dissolved completely in the skin within 60 min. After CU-MN dissolution, the drug diffused from the application site and migrated through the skin layers down to 2300 µm, significantly more than observed with topical application of CU-NS. This suggest that the fabricated microneedles with the incorporated CU-NS could enhance the intradermal delivery of curcumin. |
| first_indexed | 2024-04-14T06:49:08Z |
| format | Article |
| id | doaj.art-1f235bbfcc854fcfb59fa6aa4dee7b58 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-14T06:49:08Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-1f235bbfcc854fcfb59fa6aa4dee7b582022-12-22T02:07:05ZengMDPI AGPharmaceutics1999-49232019-07-0111730810.3390/pharmaceutics11070308pharmaceutics11070308Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of CurcuminSharif Abdelghany0Ismaiel A. Tekko1Lalitkumar Vora2Eneko Larrañeta3Andi Dian Permana4Ryan F. Donnelly5Medical Biology Centre, School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKMedical Biology Centre, School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKMedical Biology Centre, School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKMedical Biology Centre, School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKMedical Biology Centre, School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKMedical Biology Centre, School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKThe objective of this study was to evaluate the intradermal delivery of curcumin utilising poly(vinylalcohol) (PVA)-based microneedles loaded with curcumin nanosuspension (CU-NS). Nanoprecipitation was used to formulate the CU-NS which was then incorporated into PVA microneedles arrays consisting of 11 × 11 microneedles of conical shape, measuring 900 µm in height and with 300 µm base diameter. The nanosuspension particle size was 520 ± 40 nm, with a polydispersity of 0.27 ± 0.02 using sodium lauryl sulfate (SLS) as a stabiliser. In vitro dissolution studies in 10% <i>w/v</i> Tween 80 showed that the CU-NS dissolved significantly faster than unmodified curcumin powder, with 34% released from the CU-NS, compared to 16% from the curcumin powder after 48 h. The CU-NS-loaded microneedles (CU-MN) were able to withstand a compression force of 32 N for 30 s. Moreover, these microneedles were able to penetrate excised neonatal porcine skin to a depth of 500 µm, dissolved completely in the skin within 60 min. After CU-MN dissolution, the drug diffused from the application site and migrated through the skin layers down to 2300 µm, significantly more than observed with topical application of CU-NS. This suggest that the fabricated microneedles with the incorporated CU-NS could enhance the intradermal delivery of curcumin.https://www.mdpi.com/1999-4923/11/7/308curcumindissolving microneedlesintradermalpoly(vinylalcohol)nanosuspension |
| spellingShingle | Sharif Abdelghany Ismaiel A. Tekko Lalitkumar Vora Eneko Larrañeta Andi Dian Permana Ryan F. Donnelly Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin Pharmaceutics curcumin dissolving microneedles intradermal poly(vinylalcohol) nanosuspension |
| title | Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin |
| title_full | Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin |
| title_fullStr | Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin |
| title_full_unstemmed | Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin |
| title_short | Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin |
| title_sort | nanosuspension based dissolving microneedle arrays for intradermal delivery of curcumin |
| topic | curcumin dissolving microneedles intradermal poly(vinylalcohol) nanosuspension |
| url | https://www.mdpi.com/1999-4923/11/7/308 |
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