Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (<i>Artemisia absinthium</i>)
Plants have been used since ancient times to cure certain infectious diseases, and some of them are now standard treatments for several diseases. Due to the side effects and resistance of pathogenic microorganisms to antibiotics and most drugs on the market, a great deal of attention has been paid t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/6/353 |
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| author | Gaber El-Saber Batiha Ahmed Olatunde Amany El-Mleeh Helal F. Hetta Salim Al-Rejaie Saad Alghamdi Muhammad Zahoor Amany Magdy Beshbishy Toshihiro Murata Adrian Zaragoza-Bastida Nallely Rivero-Perez |
| author_facet | Gaber El-Saber Batiha Ahmed Olatunde Amany El-Mleeh Helal F. Hetta Salim Al-Rejaie Saad Alghamdi Muhammad Zahoor Amany Magdy Beshbishy Toshihiro Murata Adrian Zaragoza-Bastida Nallely Rivero-Perez |
| author_sort | Gaber El-Saber Batiha |
| collection | DOAJ |
| description | Plants have been used since ancient times to cure certain infectious diseases, and some of them are now standard treatments for several diseases. Due to the side effects and resistance of pathogenic microorganisms to antibiotics and most drugs on the market, a great deal of attention has been paid to extracts and biologically active compounds isolated from plant species used in herbal medicine. <i>Artemisia absinthium</i> is an important perennial shrubby plant that has been widely used for the treatment of several ailments. Traditionally, <i>A. absinthium</i> has always been of pharmaceutical and botanical importance and used to manage several disorders including hepatocyte enlargement, hepatitis, gastritis, jaundice, wound healing, splenomegaly, dyspepsia, indigestion, flatulence, gastric pain, anemia, and anorexia. It has also been documented to possess antioxidant, antifungal, antimicrobial, anthelmintic, anti-ulcer, anticarcinogenic, hepatoprotective, neuroprotective, antidepressant, analgesic, immunomodulatory, and cytotoxic activity. Long-term use of <i>A. absinthium</i> essential oil may cause toxic and mental disorders in humans with clinical manifestations including convulsions, sleeplessness, and hallucinations. Combination chemotherapies of <i>artemisia</i> extract or its isolated active constituents with the currently available antibabesial or anti-malarial drugs are now documented to relieve malaria and piroplasmosis infections. The current review examines the phytoconstituents, toxic and biological activities of <i>A. absinthium</i>. |
| first_indexed | 2024-03-10T18:57:02Z |
| format | Article |
| id | doaj.art-1f2364f76b5743cf8ef2d862a1e9ea95 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T18:57:02Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-1f2364f76b5743cf8ef2d862a1e9ea952023-11-20T04:41:39ZengMDPI AGAntibiotics2079-63822020-06-019635310.3390/antibiotics9060353Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (<i>Artemisia absinthium</i>)Gaber El-Saber Batiha0Ahmed Olatunde1Amany El-Mleeh2Helal F. Hetta3Salim Al-Rejaie4Saad Alghamdi5Muhammad Zahoor6Amany Magdy Beshbishy7Toshihiro Murata8Adrian Zaragoza-Bastida9Nallely Rivero-Perez10Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, EgyptDepartment of Biochemistry, Abubakar Tafawa Balewa University, Bauchi 740272, NigeriaDepartment of Pharmacology, Faculty of Veterinary Medicine, Menoufia University, Menouf 32511, EgyptDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71515, EgyptDepartment of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh 11421, Saudi ArabiaLaboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O. BOX 715, Makkah 21955, Saudi ArabiaDepartment of Biochemistry, University of Malakand, Chakdara Dir Lower, Khyber Pakhtunkhwa 18800, PakistanNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, JapanDepartment of Pharmacognosy, Tohoku Medical and Pharmaceutical University, 4-4-1, Komatsushima, Aoba, Sendai, Miyagi 981-8558, JapanÁrea Académica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias, Universidad Autónoma del Estado de Hidalgo, Rancho Universitario Av. Universidad km 1, EX-Hda de Aquetzalpa, 43600 Tulancingo, MexicoÁrea Académica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuarias, Universidad Autónoma del Estado de Hidalgo, Rancho Universitario Av. Universidad km 1, EX-Hda de Aquetzalpa, 43600 Tulancingo, MexicoPlants have been used since ancient times to cure certain infectious diseases, and some of them are now standard treatments for several diseases. Due to the side effects and resistance of pathogenic microorganisms to antibiotics and most drugs on the market, a great deal of attention has been paid to extracts and biologically active compounds isolated from plant species used in herbal medicine. <i>Artemisia absinthium</i> is an important perennial shrubby plant that has been widely used for the treatment of several ailments. Traditionally, <i>A. absinthium</i> has always been of pharmaceutical and botanical importance and used to manage several disorders including hepatocyte enlargement, hepatitis, gastritis, jaundice, wound healing, splenomegaly, dyspepsia, indigestion, flatulence, gastric pain, anemia, and anorexia. It has also been documented to possess antioxidant, antifungal, antimicrobial, anthelmintic, anti-ulcer, anticarcinogenic, hepatoprotective, neuroprotective, antidepressant, analgesic, immunomodulatory, and cytotoxic activity. Long-term use of <i>A. absinthium</i> essential oil may cause toxic and mental disorders in humans with clinical manifestations including convulsions, sleeplessness, and hallucinations. Combination chemotherapies of <i>artemisia</i> extract or its isolated active constituents with the currently available antibabesial or anti-malarial drugs are now documented to relieve malaria and piroplasmosis infections. The current review examines the phytoconstituents, toxic and biological activities of <i>A. absinthium</i>.https://www.mdpi.com/2079-6382/9/6/353traditional usesmedicinal herbbiological activities<i>Artemisia absinthium</i>phytochemical compounds |
| spellingShingle | Gaber El-Saber Batiha Ahmed Olatunde Amany El-Mleeh Helal F. Hetta Salim Al-Rejaie Saad Alghamdi Muhammad Zahoor Amany Magdy Beshbishy Toshihiro Murata Adrian Zaragoza-Bastida Nallely Rivero-Perez Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (<i>Artemisia absinthium</i>) Antibiotics traditional uses medicinal herb biological activities <i>Artemisia absinthium</i> phytochemical compounds |
| title | Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (<i>Artemisia absinthium</i>) |
| title_full | Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (<i>Artemisia absinthium</i>) |
| title_fullStr | Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (<i>Artemisia absinthium</i>) |
| title_full_unstemmed | Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (<i>Artemisia absinthium</i>) |
| title_short | Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (<i>Artemisia absinthium</i>) |
| title_sort | bioactive compounds pharmacological actions and pharmacokinetics of wormwood i artemisia absinthium i |
| topic | traditional uses medicinal herb biological activities <i>Artemisia absinthium</i> phytochemical compounds |
| url | https://www.mdpi.com/2079-6382/9/6/353 |
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